Malaria is one of the most severe infectious diseases. The disease burden is largest in children under 5 years in Subsaharan Africa. Development of an efficacious vaccine requires researchers to understand how immunity against the malaria parasite is acquired and maintained.
The parasite Plasmodium falciparum has an extensive genetic diversity. The aim of this project is to understand how different strains of malaria are spread and how immunity tackles the wide diversity of parasites. Our hypothesis is that one aquires immunity after the encounter of a wide range of different parasites. The continuous presence of asymptomatic infections contribute to the maintenace of immunity. We wish to investigate children in Kenya and Tanzania as well as travellers diagnosed with malaria in Sweden. We hope that our research will contribute to the development of a vaccine. Our target for funding is 200 000 SEK (approx. 27 350 USD) to finance a visiting scientist from Kenya with expertise in malaria immunology to perform specific immunological analyses at the Center for Molecular Medicine at KI.
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