Myositis is a chronic rheumatic muscle inflammation that affects approximately 1 000 people in Sweden. It is characterized by progressive muscle weakness particularly affecting thigh, shoulder and neck muscles. In the most severe forms problems with swallowing may occur.
Other organs may also be affected by inflammation like the skin, lungs and joints. Treatment today is based on glucocorticoids in high doses in combination with immunosuppressive drugs. With this treatment regimen most patients improve, at least partially, but few recover their former strength, and side effects like osteoporosis and hypertension are common. Therefore new therapies are needed. The aim of our research is to achieve improved knowledge on disease mechanisms that cause the disease, in order to develop new therapies. Our research group has made pioneer work in demonstrating favourable effects of physical training both on clinical outcome and on molecular expression in muscle tissue. We now would like to raise money to improve our work and continue searching for new therapies.
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