Multiple Sclerosis Research
Multiple slcerosis, comonly known as MS, is a chronic inflammatory disease of the central nervous system which, if left untreated, causes increasing disability for over one million people world wide. MS treatments are so far partially effective or hampered by side effects, leaving a great clinical need for intensified research on disease mechanisms and novel therapeutics. We aim to cntribute to advancement of MS research urgently needed by applying translational methods based on large patient cohorts.
In the Multiple Sclerosis Research group at CMMwe are determined to cast new light on the etiology of multiple sclerosis (MS) by seeking to understand the genetic component of the disease. We are also investigating a possible viral etiology of the disease in experimental systems. Last, we also serve neurologists by studying the development of antibodies against immunomodulatory biologic treatments. Thus, our research aims at fulfilling unmet needs of improved treatments in MS as well as adequate management of available treatments.
Our common neurological diseases, such as headache, stroke and multiple sclerosis (MS) depend to some extent on genetic factors, i.e. genes. Usually, each of these genes carry only a small risk, but may still be important to identify since they will tell us something about disease mechanisms. Such knowledge may lead to new approaches for diagnosis and treatment.
Here, our research is focused on understanding the mechanism behind a possible viral etiology of multiple sclerosis. We investigate the immune response against host proteins incorporated into viral particles. Our candidate virus is human herpesvirus 6 (HHV-6).
We also investigate response to treatment in MS with a special focus on antibody formation against immunomodulatory drugs and we run routine analyses to determine these.
In our group we are working on the cure of chronic inflammatory diseases. To our help we have biotechnological methods for the production of proteins for improved diagnostics and treatment.