We are constantly exposed to influences from the environment which affect the genome and the organism. This group is interested in immune and epigenetic mechanisms by which this is achieved. The influences that we are exposed to may predispose to later sensitivity to disease, much like the waves on a shore that move the sand grains and which only later may lead to erosion after, for instance, a heavy rain.
The group is focused on epigenetics, in particular how epigenetic mechanisms affect disease and cooperate with the genome in autoimmune diseases. Part of the research is on viral interactions with the host cell and possible implications for brain cancer.
Hepatitis C virus (HCV) affects 3% of the world population and can lead to cirrhosis and liver cancer. We interested in factors that determine the outcome of the infection; our focus is if human monoclonal antibodies can improve current treatments.