Cardiovascular diseases

Molecular vascular medicine

Lars Maegdefessel

Lars Maegdefessel
MD, PhD

” Research focus Non-coding RNAs in vascular biology and medicine Introduction Lars Maegdefessel’s Molecular Vascular Medicine group at CMM is focused on the therapeutic and biomarker potential of non-coding RNAs in vascular disease and its underlying (patho-)mechanisms, such as atherosclerosis, aneurysm formation, inflammation, and thrombosis. His research team utilizes unique human biobank material and various pre-clinical […] ”

+46 8 517 732 06
L8:03

Molecular cardiology, Cosentino

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Francesco Cosentino
Professor

” Our long term interest is to study the molecular and cellular processes underpinning vascular and cardiac dysfunction in the context of obesity and diabetes. Key aspects of the research program also include the link between environmental factors, metabolic disease and premature cardiovascular ageing. These objectives are accomplished by a translational approach aimed to characterize cardiovascular […] ”

+46-8-517 73535
L8:02

Translational cardiology, Bäck

Magnus Bäck

Magnus Bäck
MD, PhD

” Our research applies translational aspects to study mechanisms of cardiovascular disease and identify novel potential therapeutic targets. Based at the Center for Molecular Medicine at Karolinska Institutet and the Cardiology Department of Karolinska University Hospital, we integrate studies of human tissues and cells using advanced molecular biology with the clinical characteristics of disease. We also […] ”

+46 8 517 764 19
L8:03

Experimental cardiovascular research

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Peder Olofsson
Senior researcher

” Our research is focused on immune mechanisms in atherosclerosis development. Atherosclerosis is an inflammatory disease. The disease is associated with systemic immune responses and signs of inflammation. Its lesions are filled with immune cells that can orchestrate and effect inflammatory responses. In fact, the first lesions of atherosclerosis consist of macrophages and T cells. Unstable […] ”

+46 8 517 716 67
L8:03

Cardiology

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John Pernow
Professor, MD

” The work of our group is focusing on two interacting research areas: 1. endothelial cell biology and function and 2. protection from myocardial ischemia-reperfusion injury. These areas are explored in basic studies as well as clinical investigations. We investigate the role of biologically important factors derived from endothelial cell in ischemic heart disease, atherosclerosis and […] ”

+46 8 517 758 76
N3:05

Cardiovascular genetics & genomics

Per Eriksson_KI

Per Eriksson
Professor

” The mission of the group is to unravel the etiology and pathophysiological mechanism underlying atherosclerosis, arterial thrombosis and aneurysm formation. This is pursued by a combination of physiological, biochemical and molecular genetics and genomics studies in vivo in humans and in model systems as well as functional molecular genetic studies in in vitro and ex […] ”

+46 8 5177 32 02
L8:03

Clinical chemistry

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Thomas Renné
Professor, MD

” Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. This system starts a cascade of procoagulant and proinflammatory reactions via the intrinsic pathway of coagulation, and the bradykinin-producing kallikrein-kinin system, respectively. […] ”

+46 8 517 733 90, +46 707 73 01 09
L2:05

Vascular surgery

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Ulf Hedin
Professor, MD

” Vascular disease is the leading cause of death and disability in the western world. In order to prevent disease development and develop preventive strategies, a complete understanding of basic cellular and molecular mechanisms is necessary. Our group utilizes a translational platform with advanced cell- and molecular biology, animal models in combination with patient centred research […] ”

+46 8 517 721 75
L8:03

Neural control of inflammation - Olofsson

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Peder Olofsson
Senior researcher

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+46 8 517 716 67
L8:03

Vessel wall healing - Hedin

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Ulf Hedin
Professor, MD

” The project is aimed at unraveling the pathophysiology of healing processes in the vessel wall and is more specifically based on studies of the molecular and cellular mechanisms that regulate the function of smooth muscle cells (SMCs) in atherosclerosis with particular focus on plaque stability and in the formation of intimal hyperplasia in in-stent stenosis, […] ”

+46 8 517 721 75
L8:03

Leukocyte-Endothelial Interactions in Large Vessel Biology

Einar Eriksson

Einar Eriksson
MD, PhD, Associate Professor, Affiliated

” Inflammatory recruitment of blood cells to the vascular wall is of importance in large vessel pathology including atherosclerosis, arthritis, and intimal hyperplasia in response to vascular intervention. We use various microscopic techniques on live mice and whole mount tissues to study the mechanisms that guide transition of leukocytes from free flow to extravasation. At present, […] ”

+46 8 517 700 00
L5:01

Vessel wall signaling - Roy

Joy Roy2

Joy Roy
MD, PhD, Associate Professor

” Homeostasis in the vessel wall is maintained by signaling between the different cell types and the matrix and recently also been shown to be affected by the flowing blood, also known as shear stress. Our aim is to identify the critical signaling mechanisms in physiological states and understand how they are affected during vascular injury. […] ”

+56 8 517 793 55
L5:01

Cellular and molecular mechanisms in pulmonary hypertension - Tran Lundmark

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Karin Tran Lundmark
MD, PhD, Researcher

” Pulmonary hypertension (PH) is a life‐threatening condition, which untreated leads to right heart failure and death. The disease is characterized by three major pathological changes in the pulmonary arterial wall: 1) vasoconstriction, 2) cell proliferation and remodeling, and 3) in situ thrombosis. Current treatment with prostaglandin analogues, nitric oxide, endothelin receptor antagonists, and phosphodiesterase‐5 inhibitors, […] ”

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Team Brion

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Laura Brion
PhD, Postdoc

” Our mission is to understand cellular mechanisms behind the translation of receptor signals and their integration into signaling networks. Achieving temporal and spatial organization between receptor pathways and effectors is essential for reaching specificity and for avoiding deletereous crosstalk. Major goals are to better define mechanisms of disease that could lead to reliable therapeutic approaches […] ”

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Innate immunity in atherosclerosis – Yan

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Zhong-Qun Yan
MD, PhD, Docent

” Innate signaling pathways of the immune system are important for atherosclerotic disease. Among other cell types, we are particularly interested in the macrophage and its function in the disease process.   If you would like to support this area of research you could do that by using the following accounts: BG 628-4418 PG 514114-8 State: […] ”

+4 68 517 732 07
CMM L8:03

B-cell biology - Malin

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Stephen Malin
PhD, Assistant Professor

” If you would like to support this area of research you could do that by using the following accounts: BG 628-4418 PG 514114-8 State: Stephen Malin If you are outside of Sweden, please use the following information: Bank: SEB, Stockholm, Sweden Account No. 5201-11 370 12 Iban-number: SE16 5000 0000 0520 1113 7012 Bic-code (the […] ”

+46 8 517 700 00
CMM L8:03

CMM Research Groups

NEUROGENETICS AND PSYCHIATRIC DISEASES

GENETIC DISEASES

INFLAMMATORY DISEASES

Cardiovascular and Metabolic Diseases