Epigenetic Effects of Endocrine Disrupting Chemicals: from mechanisms to human health
Speaker: Joëlle Rüegg
Department of Clinical Neuroscience (CNS) & Epigenetic Toxicology team at Swetox
Location: Lecture Hall, CMM L8:00
Host: Tomas Ekström
Background: We are exposed to a cocktail of thousands of chemicals on an everyday basis, some of which have the property to interfere with our endogenous hormonal system. Exposure to these so-called endocrine disrupting chemicals (EDCs) is associated with a number of diseases drastically increasing in the population, such as obesity, infertility, and neurodevelopmental disorders. Epigenetics represents the most likely mechanism underlying later life diseases resulting from early life exposures as epigenetic processes drive early development. Thus, epigenetic changes induced by EDCs could be highly valuable markers to predict disease susceptibility.
Our team combines mechanistic studies in cellular models, analyses of exposed experimental animals, and insights from epidemiological data (see figure). Using this interdisciplinary approach, we hope to contribute to clarify the risks posed by EDC-exposure in early life and to develop methods assessing epigenetic endpoints that can be ultimately integrated into chemical risk assessment procedures.