Avhandlingar från gruppen

Andreas Warnecke – Post-translational modifications of Myelin Oligodendrocyte Glycoprotein in CNS autoimmunity

14th June 2016

Andreas joined the lab to take on a previously initiated project aiming to explore the underlying cause of autoantigenicity. Andreas’ attention to detail, willingness to improve on existing method protocols and exemplary use of the Electronic Lab Notebook were an inspiration to everyone. His desire to disprove hypotheses and to follow the data trail also led to new insights in our understanding of the complexity of autoantigenicity.

 

Roham Parsa – Innate regulation of the adaptive immune system during autoimmunity

12th June 2015

Roham conducted a Masters project while studying at KTH, and joined the lab to continue this project concerning macrophage biology. Roham’s tenacity and work ethic has led to a number of important milestones for the lab, including the first demonstration that adoptive transfer myeloid therapy could prevent Type 1 Diabetes, which set off our myeloid therapy programme. His desire to develop conditional knockout mouse strains led to a serendipitous novel finding concerning neutrophil functionality, and has laid the foundation for much of the current research the lab conducts.

 

Sohel Mia – Myeloid cells in autoimmune diseases
11th April 2014

Sohel came to an empty lab following my parental leave of absence and began the hard work of kick-starting my research programme. He was the first in the lab to start to use human macrophages, something which we had no prior experience of, and which proved to be very different from rodent cells. Sohel made the landmark observation that even though they are intrinsically pro-inflammatory, the macrophages from an MS patient could be successfully immunomodulated through specific stimulation with a panel of cytokines, developing an anti-inflammatory phenotype that could successfully modulate pro-inflammatory macrophages from the same individual.

 

Åsa Andersson – Macrophages : As central inflammatory mediators and as targets for therapeutic interventions

27th January 2006

As we had begun to focus our interests on macrophages, Åsa’s thesis work was important in helping us to begin to understand these enigmatic cells. One of Åsa’s important findings was that genotype affected phenotype, demonstrating that macrophages derived from different mouse strains had different properties despite being stimulated in identical fashion.

 

Maja Wållberg – Modulation of immune responses in experimental autoimmune encephalomyelitis

4th May 2005

Maja’s thesis work was pivotal to the activities of my research group as she made three important discoveries. The first was that post-translationally modified MOG had increased potential to induce disease, indicating that autoantigen-based therapies should take this into account. Maja also demonstrated that autoantigen vaccination is an effective long-term therapy in experimental neuroinflammation. Most importantly, Maja used a live parasite infection to modulate the clinical course of EAE, and went on to demonstrate that this protective effect was due to the parasite-mediated induction of anti-inflammatory macrophages. This finding was the basis of our current translational research programme.

 

Judit Wefer – Studies of cellular pathogenesis in experimental autoimmune encephalomyelitis

10th September 2004

Judit’s work extended the important characterisation of our DBA/1 mouse of MOG-EAE through the use of specific gene-deleted mouse strains. In addition, she characterised the mechanism of action of DNA vaccination as a successful therapeutic intervention.

 

Khairul-Bariah Abdul-Majid – Pathogenesis of myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis in DBA/1 mice

11th January 2002

This thesis was a landmark as it signified our entrance onto the stage of EAE autoimmunity. Karol was able to establish a mouse EAE model in DBA/1 mice with two important characteristics that sets it above many other models – namely, the minimal use of adjuvant (no pertussis toxin) and a pathology resembling human MS pathology (brain and spinal cord demeylination).

 

PhD theses with Robert Harris as co-supervisor:

Nataliya TarasovaEstablishing a proteomics-based monocyte assay to assess differential innate immune responses – 17th June 2016

Anna Maria MarinoExperimental combination therapy of brain cancer cell models – 7th December 2012

Melanie Thessen HedreulGenetic and immunological regulation of neuroinflammation – 15th June 2012

Elizabeth Jedell – Polycystic ovary syndrome: Studies of affective symptoms in association with sex steroids and evaluation of electroacupuncture and physical exercise – 17th December 2010

Alan Gillett – Genetic and Immunological Mechanisms Regulating Neuroinflammation – 19th November 2010

Ammenai Beyeen – Definition of genetic and pathogenic mechanisms regulating neuroinflammation – 12th November 2010 

Jan Ottervald Proteomics in neurological disease – 27th November 2009

Anna Ökvist – Synaptic plasticity in drug abuse disorders: Studies of the human post-mortem brain – 13th February 2009

Ruxandra Covacu – Adult neural stem cells in neuroinflammation
24th January 2008

Monica Marta – Gene regulation and immune mechanisms in multiple sclerosis experimental models – 25th September 2007

Maria Hindersson – Coxsackie B virus pathogenesis in mice – 8th June 2006

Samer Sourial – Functional studies on the interaction of immunoglobulins with HIV-2 envelope – 7th October 2005

John Andersson – Experimental Chagas disease – 4th June 2003

Maha Hamadien – Parasite signalling and host responses in experimental and human African trypanosomiasis – 29th August 2002

Saad Muhallab – T cell production of cytokines, neurotrophins and MHC regulation in autoimmune neuroinflammation – 14th June 2002

Ahmed Sharafeldin – Immunological studies in the brain and signaling pathways in experimental African trypanosomiasis – 14th December 2001 

Dan Sunnemark – Immunopathogenesis of experimental Chagas’ disease – 20th May 1998 

Azael Saldana – Immunobiochemical significance of Trypanosoma rangeli in the study of Trypanosoma cruzi – 19th November 1997 

Jessica Vasquez –

CMM Research Groups

NEUROGENETIK OCH PSYKIATRISKA SJUKDOMAR

GENETISKA SJUKDOMAR

INFLAMMATORISKA SJUKDOMAR

KARDIOVASKULÄRA OCH METABOLA SJUKDOMAR