Utvalda publikationer

1. Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R, Eloranta ML, J Ni Gabhann, Winqvist O, Sundelin B, Jefferies C, Rozell B, Kuchroo V, Wahren-Herlenius M. Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by dysregulating the IL-23/Th17 pathway. J Exp Med. 2009 Aug 3;206(8):1661-71. Pubmed

2. Strandberg L, Ambrosi A, Jagodic M, Dzikaite V, Janson P, Khademi M, Salomonsson S, Ottosson L, Klauninger R, Adén U, Sonesson SE, Sunnerhagen M, de Graaf KL, Kuchroo VK, Achour A, Winqvist O, Olsson T, Wahren-Herlenius M. Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block. J Immunol. 2010 Sep 15;185(6):3574-82. Pubmed

3. Espinosa A, Hennig J, Ambrosi A, Anandapadmanaban M, Sandberg M, Sheng Y, Nyberg F, Arrowsmith C, Sunnerhagen M, Wahren-Herlenius M. Anti-Ro52 autoantibodies from patients with Sjögren’s syndrome inhibit the E3 ligase activity of Ro52 by blocking the E3:E2 interface. J Biol Chem. 2011 Oct 21;286(42):36478-91. Pubmed

4. Ambrosi A, Dzikaite V, Park J, Strandberg L, Kuchroo VK, Herlenius E, Wahren-Herlenius M. Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model. Ann Rheum Dis. 2012 Mar;71(3):448-54. Pubmed

5. Ambrosi A, Salomonsson S, Eliasson H, Zeffer E, Skog A, Dzikaite V, Bergman G, Fernlund E, Tingström J, Theander E, Rydberg A, Skogh T, Ohman A, Lundström U, Mellander M, Winqvist O, Fored M, Ekbom A, Alfredsson L, Källberg H, Olsson T, Gadler F, Jonzon A, Kockum I, Sonesson SE, Wahren-Herlenius M. Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern. Ann Rheum Dis. 2012 Mar;71(3):334-40. Pubmed

 6. Rusakiewicz S, Nocturne G, Lazure T, Semeraro M, Flament C, Caillat-Zucman S, Sène D, Delahaye N, Vivier E, Chaba K, Poirier-Colame V, Nordmark G, Eloranta ML, Eriksson P, Theander E, Forsblad-d’Elia H, Omdal R, Wahren-Herlenius M, Jonsson R, Rönnblom L, Nititham J, Taylor KE, Lessard CJ, Sivils KL, Gottenberg JE, Criswell LA, Miceli-Richard C, Zitvogel L, Mariette X. NCR3/NKp30 Contributes to Pathogenesis in Primary Sjogren’s Syndrome. Sci Transl Med. 2013 Jul 24;5(195):195ra96. Pubmed

 7. Sjöstrand M, Ambrosi A, Sullivan J, Malin S, Kuchroo VK, Espinosa A,Wahren-Herlenius M. Expression of the immune regulator TRIM21 is controlled by interferon regulatory factors. J Immunol. 2013 Oct 1;191(7):3753-63. Pubmed

8. Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Cunninghame Graham DS, Grandits ME, Nazmul-Hossain ANM, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Rönnblom L, Nordmark G, Ng WF for UK primary Sjögren’s syndrome registry, Mariette X, Anaya JM, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Moser Sivils KL. Identification of multiple genetic variants associated with Sjögren’s syndrome involved in both the innate and adaptive immune responses. Nature Genetics. 2013 Nov;45(11):1284-92. Pubmed

9. Meisgen S, Östberg T, Salomonsson S, Ding B, Eliasson H, Mälarstig A, Alfredsson L, Klareskog L, Hamsten A, Olsson T, Axelsson T, The Swedish Congenital Heart Block Study Group, Gadler F, Jonzon A, Sonesson SE, Kockum I, Wahren-Herlenius M. The HLA locus contains novel foetal susceptibility alleles for congenital heart block with significant paternal influence. J Intern Med. 2014 Jun;275(6):640-51. Pubmed

 10. Wahren-Herlenius M, Thomas Dörner. Immunopathogenic mechanisms of systemic autoimmune disease. Lancet. 2013 Aug 31;382(9894):819-31. Pubmed

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