Signaleringsnätverk i membran

Valda publikationer

• Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability FASEB J 26:3230-3239, 2012
• Increases in intracellular sodium activate transcription and gene expression via the salt-inducible kinase 1 network in an atrial myocyte cell line Am J Physiol Heart Circ Physiol. 303: H57-H65, 2012
• Salt-inducible kinase 1 influences Na,K-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure J Hypertens. 29: 2395-2403, 2011.
• Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure Biochim Biophys Acta. 1802:1140-9, 2010
• Blocking the salt-inducible kinase 1 network prevents the increases in cell sodium transport caused by a hypertension-linked mutation in human alpha-adducin. J Hypertens. 27: 2452-2457, 2009.
• Pals-associated tight junction protein functionally links dopamine and angiotensin II to the regulation of sodium transport in renal epithelial cells Br J Pharmacol. 158: 486-493, 2009.
• SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways Pflugers Arch. 458: 613-619, 2009.
• SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process Proc Natl Acad Sci U S A. 104:16922-16927, 2007
• Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium Circ Res. 2004 Nov 26;95(11):1100-8
• Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta J Clin Invest. 111: 1057-1064, 2003.
• Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+-ATPase alpha subunit and regulates its trafficking Proc Natl Acad Sci U S A. 97: 6556-6561, 2000.
• G protein-coupled receptors regulate Na+,K+-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrin Proc Natl Acad Sci U S A. 97: 3242-3247, 2000.