Göran Holm

Processionary moths with larvae that carry noxious hairs (setae) are present worldwide. A population of Thaumetopea pinivora (TP) is present at the southern part of Gotland. This larvae has increased in size and become a major concern among people living in or visiting the area. Among persons who stayed in the area during the summer 2005, 20% reported symptoms after contacts with larvae, one third of whom with severe symptoms. The TP larvae carry setae of microscopic size, which can be transferred to humans via air or by direct contact. The skin affected become itching and swelling with redness and blister formation. Inhaled setae may cause asthmatic reactions and oral or nasal contacts may give rhinitis and local inflammation. Severe gastrointestinal distress has been noted after ingestion. On rare occasions, anaphylactic reactions may develop. The mechanisms behind symptoms are only partly known. Acute allergic reactions towards setae associated proteins have been described. These observations suggest that other mechanisms than rapid allergic reactions contribute to the symptoms. Our studies are aimed to elucidate the specific T-cell-mediated immune response, inflammatory reactions and clinical consequences following exposure. The hypothesis that setae and purified setae molecules activate cell-mediated immune and inflammatory reactions is studied.


Om du skulle vilja stödja detta forskningsområde kan du göra det via följande konton:

BG 628-4418
PG 514114-8
Ange: Göran Holm

Om du befinner dig utanför Sverige, vänligen använd följande information:

Bank: SEB, Stockholm, Sweden
Kontonummer: 5201-11 370 12
Iban-nummer: SE16 5000 0000 0520 1113 7012
Bic-kod (bankens elektroniska adress): ESSESESS
Kontoinnehavare: Stiftelsen Centrum för Molekylär Medicin
L8:05, Karolinska Universitetssjukhuset
171 76 Stockholm, Sweden

CMM Research Groups