Intracellulär signalering – Nord
Inflammatory lung diseases such as asthma, sarcoidosis and chronic obstructive pulmonary disease (COPD) are common diseases with a need for development of novel innovative treatments. To provide a basis for development of new therapeutic strategies, we use a translatory research approach linking basic mechanistic studies with clinical research to increase the molecular understanding of inflammatory lung diseases.
Our studies are centered around mechanisms inside the cell that controls inflammatory processes and cellular differentiation, with a focus on regulation of gene expression. We use advanced cell and molecular biology methods to study lung cells from the sick patient obtained via bronchoscopy, allowing us to directly study the diseased organ in combination with mouse and cell models.
During the last years we have established a previously unknown role for the transcription factors C/EBPs in the regulation of lung genes and in mediating the effects of corticosteroids in lung, central in the treatment of inflammatory lung diseases. We have also found that C/EBP-activity is increased in the lungs of healthy smokers, whereas smokers that develop COPD lack this increase This inability to activate C/EBPs could play a role in the pathogenesis of COPD, as C/EBPs are known to activate many genes involved in defense mechanisms, including anti-oxidative genes and genes within the innate immune system, all involved in the pathogenesis of COPD. The decreased C/EBP-activity in COPD could also help explain the relative resistance to corticosteroid-treatment that characterizes this disease.
Om du skulle vilja stödja detta forskningsområde kan du göra det via följande konton:
Ange: Magnus Nord
Om du befinner dig utanför Sverige, vänligen använd följande information:
Bank: SEB, Stockholm, Sweden
Kontonummer: 5201-11 370 12
Iban-nummer: SE16 5000 0000 0520 1113 7012
Bic-kod (bankens elektroniska adress): ESSESESS
Kontoinnehavare: Stiftelsen Centrum för Molekylär Medicin
L8:05, Karolinska Universitetssjukhuset
171 76 Stockholm, Sweden