Kärlväggssignalering – Roy

Homeostasis in the vessel wall is maintained by signaling between the different cell types and the matrix and recently also been shown to be affected by the flowing blood, also known as shear stress. Our aim is to identify the critical signaling mechanisms in physiological states and understand how they are affected during vascular injury. In particular, we are focusing on insulin‐like growth factor 1 and shear stress related signaling in smooth muscle cells and their role in vessel wall injury. We aim to identify target critical signaling pathways in order to attenuate atherosclerosis progression and complications for example plaque rupture and improve results after vascular surgery. We use in vitro cell culture models, small animal models and even clinical databases and patient samples to test our hypotheses

 

Om du skulle vilja stödja detta forskningsområde kan du göra det via följande konton:

BG 628-4418
PG 514114-8
Ange: Joy Roy

Om du befinner dig utanför Sverige, vänligen använd följande information:

Bank: SEB, Stockholm, Sweden
Kontonummer: 5201-11 370 12
Iban-nummer: SE16 5000 0000 0520 1113 7012
Bic-kod (bankens elektroniska adress): ESSESESS
Kontoinnehavare: Stiftelsen Centrum för Molekylär Medicin
L8:05, Karolinska Universitetssjukhuset
171 76 Stockholm, Sweden

CMM Research Groups

NEUROGENETIK OCH PSYKIATRISKA SJUKDOMAR

GENETISKA SJUKDOMAR

INFLAMMATORISKA SJUKDOMAR

KARDIOVASKULÄRA OCH METABOLA SJUKDOMAR