Skin Immunology – Eidsmo
Psoriasis is a T cell driven inflammatory disease of primarily the skin that affects 2-3 % of the Swedish population. Effective treatment suppresses the chronic inflammation but cure is currently not feasible. Psoriasis often return in the same areas of the skin and it seems that resolved skin contains a hidden disease memory.
We aim to dissect the skin resident disease memory in psoriasis. We have a particular interest in pathogenic epidermal tissue resident memory T cells (Trm) and dendritic cells (DCs). Tissue resident memory T cells (Trm) are recently described epithelial T cells that are retained in the skin after viral infection in mice (Gebhardt et al). These cells are perfectly placed to form a pathologic disease memory in recurrent and site specific inflammation.
We perform functional studies to understand what influences and activates T cells and dendritic cells in the human skin during psoriasis. We recently obtained a FACSJazz cell sorter for to facilitate in vitro experiments of tissue derived T cells and DCs. We plan to investigate how T cells affect and drive inflammation in the skin in experimental models of inflammation. Through unraveling mechanisms of tissue immunopathology in psoriasis we ultimately aim to find new ways to treat psoriasis.
Om du skulle vilja stödja detta forskningsområde kan du göra det via följande konton:
Ange: Liv Eidsmo
Om du befinner dig utanför Sverige, vänligen använd följande information:
Bank: SEB, Stockholm, Sweden
Kontonummer: 5201-11 370 12
Iban-nummer: SE16 5000 0000 0520 1113 7012
Bic-kod (bankens elektroniska adress): ESSESESS
Kontoinnehavare: Stiftelsen Centrum för Molekylär Medicin
L8:05, Karolinska Universitetssjukhuset
171 76 Stockholm, Sweden