Asset Publisher

New findings about how Parkinson's disease develops

New findings about how Parkinson's disease develops

A new study by researchers at CMM shows that the protein alpha-synuclein, which accumulates in patients with Parkinson’s disease, occurs bound to lipoprotein particles in cerebrospinal fluid, which may explain how the disease spreads in the nervous system. The study is published in the scientific journal PNAS.

Some 23,000 people in Sweden suffer from Parkinson’s disease, which is the second most common neurodegenerative disease after Alzheimer’s disease. There is still today no way to slow the progress of the disease. Parkinson’s disease is thought to be caused by harmful accumulations of the protein alpha-synuclein in the nerve cells. As the disease progresses, the protein spreads to new parts of the nervous system, but no-one has been able to show how the spread occurs.

“We can now show that alpha-synuclein binds to lipoprotein particles in cerebrospinal fluid and this may contribute to how alpha-synuclein spreads,” says Per Svenningsson, Professor in Neurology at the Department of Clinical Neuroscience at Karolinska Institutet.

Professor Per Svenningsson                                      

Photo: Ulf Sirborn

 

The study "α-synuclein−lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients

was published in PNAS   3 July 2019, (https://doi.org/10.1073/pnas.1821409116).

 

Read the full news story at Karolinska Institutet website.

 

NEWS

Grant from Forte to Xia Jiang

Grant from Forte to Xia Jiang Xia Jiang, Assistant Professor in Ingrid Kockum’s Group at CMM, is one of the 11 researchers from Karolinska Institutet who received research grants as a part...

Improved Patient Classification in Chronic Lymphocytic Leukemia

Improved Patient Classification in Chronic Lymphocytic Leukemia CMM Group Leader Professor Richard Rosenquist Brandell, is one of the main coauthors of a large study recently published in ...

Finding Molecular Links between Stress and Depression

Finding Molecular Links between Stress and Depression Vasco Sousa, researcher in Per Svenningson’s Group at CMM, is the first author of a study with the title “P11 deficiency increases...

Nanna Svartz Scholarship for Outstanding Research in Rheumatology 2020

Nanna Svartz Scholarship for Outstanding Research in Rheumatology 2020 The Nanna Svartz scholarship for outstanding research in rheumatology 2020 is awarded to Marie Wahren-Herlenius,...

Susanna Brauner Awarded the Swedish Society of Medicine's Translational Research Prize

Susanna Brauner Awarded the Swedish Society of Medicine's Translational Research Prize Susanna Brauner , Assistant professor and CMM researcher (Fredrik Piehl’s Team) has received the...

Ning Xu Landén 2020 Year’s Winner of the LEO Foundation Award

Ning Xu Landén 2020 Year’s Winner of the LEO Foundation Award Associate Professor Ning Xu Landén, Group Leader at CMM is the winner of this year’s LEO Foundation Award in Region EMEA...

Nils Landegren receives ERC Starting Grant for studying sex differences in the human immune system

Nils Landegren receives ERC Starting Grant for studying sex differences in the human immune system Photo: Hans Ericksson, SSMF Nils Landegren , Researcher at CMM, has been awarded...

Verification project of SARS-CoV-2 antibody tests receives funding from Swelife

Verification project of SARS-CoV-2 antibody tests receives funding from Swelife Photo: Mattias Bronge, Karolinska Institutet A validation project of new SARS-CoV-2 antibody tests,...

Grant to Qiaolin Deng for the single-cell technology core at CMM

Grant to Qiaolin Deng for the single-cell technology core at CMM Qiaolin Deng, private photo We congratulate Associate Professor and CMM Team Leader Qiaolin Deng who received a SFO...

Identification of key gene for improvement of multiple sclerosis treatments

Identification of key gene for improvement of multiple sclerosis treatments Karl Carlström and Fredirk Piehl. Photo: Stefan Zimmermann   CMM researcher Karl Carlström and...