Developing novel immunotherapies for treatment of autoimmune diseases
We design and test novel therapeutic interventions for modulation of rodent models of inflammation, with the intention of innovative technology transfer to treatment of patient groups.
We develop antigen-specific vaccination protocols, such as autoantigen in adjuvants that induce regulatory T cell subsets.
We have also developed a novel cell transfer therapy based on specifically activated macrophages/microglia/monocytes. We test whether such approaches can induce short-term and long-term protection in experimental models, and define the immunological basis of the protective mechanisms. The models currently being tested include MS, Alzheimer’s disease, Rheumatoid Arthritis, Type 1 Diabetes, Stroke, Pain and Brain Tumours (Glioblastoma multiformes).
Myeloid cell therapy proposal (Webcast):
Click on the links to the different disease settings: