Asset Publisher

Nils Landegren receives ERC Starting Grant for studying sex differences in the human immune system

Nils Landegren receives ERC Starting Grant for studying sex differences in the human immune system

Photo: Hans Ericksson, SSMF

Nils Landegren, Researcher at CMM, has been awarded the 2020 European Research Council (ERC) Starting Grant. The program aims at supporting new research leaders.

The funded project, SEXimmune, entails a broad investigation of the biological basis of sex differences in the human immune system. Women are four times more likely to develop autoimmune diseases, while men as a group have worse outcomes of infectious diseases such as COVID-19. Nils and his team will combine human model systems and population-based approaches to investigate the factors underlying these sex differences.

To understand the role of sex hormones, the team will study longitudinal samples from women and men undergoing sex reassignment treatment. A combination of large-scale technologies will be applied to follow how a broad range of immune parameters are affected by sex hormone transition.

As a complementary model to capture the effects of the chromosomal sex, studies will be conducted using samples from mosaic individuals who harbor immune cells with either female or male karyotypes among their peripheral bloodcells. Single cell transcriptomic analysis will be applied to compare these cell populations, thereby revealing the influence of chromosomal sex against an otherwise fixed genetic and hormonal background.

The model systems will be combined with population-level studies – taking advantage of new data on sex hormone levels and sex chromosome karyotypes in 500,000 women and men from the UK Biobank, in order to determine how they influence the risk of autoimmune disease.  

We congratulate Nils Landegren and wish him good luck with these important investigations.

 

To read more, click here:  https://news.ki.se/they-are-awarded-the-2020-erc-stg

NEWS

Ning Xu Landén 2020 year’s winner of the LEO Foundation Award

Ning Xu Landén 2020 year’s winner of the LEO Foundation Award Associate Professor Ning Xu Landén, Group Leader at CMM is the winner of this year’s LEO Foundation Award in Region EMEA...

Nils Landegren receives ERC Starting Grant for studying sex differences in the human immune system

Nils Landegren receives ERC Starting Grant for studying sex differences in the human immune system Photo: Hans Ericksson, SSMF Nils Landegren , Researcher at CMM, has been awarded...

Verification project of SARS-CoV-2 antibody tests receives funding from Swelife

Verification project of SARS-CoV-2 antibody tests receives funding from Swelife Photo: Mattias Bronge, Karolinska Institutet A validation project of new SARS-CoV-2 antibody tests,...

Grant to Qiaolin Deng for the single-cell technology core at CMM

Grant to Qiaolin Deng for the single-cell technology core at CMM Qiaolin Deng, private photo We congratulate Associate Professor and CMM Team Leader Qiaolin Deng who received a SFO...

Identification of key gene for improvement of multiple sclerosis treatments

Identification of key gene for improvement of multiple sclerosis treatments Karl Carlström and Fredirk Piehl. Photo: Stefan Zimmermann   CMM researcher Karl Carlström and...

Sweden’s innovation agency Vinnova extends the funding of Genomic Medicine Sweden with additional SEK 36 million

Sweden’s innovation agency Vinnova extends the funding of Genomic Medicine Sweden with additional SEK 36 million Sweden’s innovation agency Vinnova extends the funding of the national...

The Swedish Heart-Lung Foundation major grant 2020 goes to Marie Wahren-Herlenius

The Swedish Heart-Lung Foundation major grant 2020 goes to Marie Wahren-Herlenius Professor Marie Wahren-Herlenius, Group Leader at CMM, has received the biggest yearly grant in Sweden...

Simple blood test may help predict MS progression, study finds

Simple blood test may help predict MS progression, study finds Photo: Ali Manouchehrinia   A study led by the CMM researchers Ali Manouchehrinia (first...

Experimental study finds new substances with higher specificity and therapeutic potential in multiple sclerosis

Experimental study finds new substances with higher specificity and therapeutic potential in multiple sclerosis   Karl Carlström, photo Stefan Zimmerman   Karl...

Early exposure to cannabis boosts young brains' sensitivity to cocaine, rodent study shows

Early exposure to cannabis boosts young brains' sensitivity to cocaine, rodent study shows A study made by Philippe Melas from Karolinska Institutet together with colleagues at Columbia...