Novel mechanisms of atherosclerotic plaque (in)stability governed by smooth muscle cells

Novel mechanisms of atherosclerotic plaque (in)stability governed by smooth muscle cells

Translational Vascular Medicine lead by Ljubica Matic is a translational Team composed of basic researchers with expertise in molecular biology and pharmacology, and clinically active vascular surgeons. The Team applies integrative analyses combining bioinformatic and clinical data studies with murine models of vascular injury and disease, while in vitro systems based on primary cells and tissue explants are utilized for functional and mechanistic investigations.

Vascular diseases comprise conditions like atherosclerosis, aortic aneurysms and restenosis after surgical interventions, contributing to the high overall cardiovascular mortality. Pathological vessel changes are generally featured by inflammatory, apoptotic and remodeling processes involving lipids, immune and smooth muscle cells (SMCs). Given the capacity of SMCs to provide tissue integrity, we hypothesize that understanding of mechanisms that regulate their function can yield new strategies to prevent vascular complications. Therefore, we focus on novel molecular mechanisms of vascular disease particularly related to SMCs, as well as on biomarkers and therapeutic approaches in carotid atherosclerosis.

Our ultimate goal is to develop new targets for stabilizing therapies or imaging modalities aimed at early detection of vulnerable atherosclerotic plaques and patients. Our dedication to translational research in this area, as well as collaborations with numerous groups worldwide (Stanford, King’s College, Ottawa Heart Institute, Munich Technical University, etc.), have already demonstrated how a combination of clinical and experimental research has the true potential to advance the knowledge of vascular disease. 

Donations

Donations

 

If you would like to support this area of research

you could do that by using Swish transfer. 

Our Swish number is 123-245 79 76

 

Always state the name of group/team leader in order for us to allocate the gift properly. 

Or you can also use the following accounts:

BG: 628-4418
PG: 514114-8

Always state the name of group/team leader in order for us to allocate the gift properly. 

If you are outside of Sweden, please use the following information:

Bank: SEB, Stockholm, Sweden
Account No. 5201-11 370 12
Iban-number: SE16 5000 0000 0520 1113 7012
Bic-code (the bank´s electronic address): ESSESESS
Account holder: Center for Molecular Medicine Foundation
L8:05, Karolinska University Hospital
171 76 Stockholm, Sweden

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Team leader

Ljubica Matic

E-mail

ljubica.matic@ki.se

Job title

Assistant professor

House

BioClinicum J8:20