Chronic inflammatory disease mechanisms
In order to understand the mechanisms underlying disease, we use two approaches: study of particular cells or molecules in vivo using experimental disease models, or study of particular cells or molecules in vitro.
Alternatively activated macrophages. R.Parsa
We have developed a novel experimental model of multiple sclerosis in the DBA/1 mouse, (MOG-induced Experimental Autoimmune Encephalomyelitis (MOG-EAE)) and we also use the NOD model of spontaneous Type 1 diabetes. Both these inflammatory settings are tissue damaging and related to proinflammatory immune responses. We also employ a model of Glioblastoma multiformes to study brain tumour development which is conversely associated with an anti-inflammatory immune component. We recently began working with an Alzheimer’s disease, which we believe is also an inflammatory condition.
We believe antigen presenting cell (APC) function to be a key element of autoimmune dysfunction, and thus focus on defining APC phenotypes in rodent strains with different EAE susceptibilities, and in study of specific APC molecules which we hypothesize are important in susceptibility to disease. These studies include comparative studies of macrophages, dendritic cells and microglia (brain macrophages).