• About
Karolinska institutet
Karolinska universitetssjukhuset

Per-Johan Jakobsson Group


We aim to explore targets and pathways in rheumatic and related diseases driven by inflammation using a pharmacological approach. We focus on the arachidonic acid cascade and the development of mPGES-1 inhibitors. We also investigate biomarkers in rheumatoid arthritis and systemic autoimmune inflammatory diseases and investigate e.g. the pathophysiological role of associated antigens and autoantibodies. Analytically, we e.g. perform proteomics, lipid metabolomics and cytokine profiling.

There is growing interest in society and in the scientific community to decipher the mechanisms of action of plant-based traditional Chinese medicine using evidence-based research methods. For this, we have established a research project called Joint Research Base for Chinese Medicine (JRBCM) at KI. The overall aim of JRBCM is to explore Chinese traditional herbal-based medicine as a source for evidence-based drug discovery and development. The JRBCM will assess the large amount of existing clinical data and explore the vast and unique resource of Chinese traditional medicine, with the ultimate aim of drug discovery and drug development for clinical use. The research is focused on isolation of bioactive compounds, exploration of their modes of action alone or in combinations, and ultimately development of novel medication for the treatment of and possibly prevention of rheumatoid arthritis.

Group Leader

Per-Johan Jakobsson, MD, specialist in rheumatology, Professor in Translational Inflammation Research, per-johan.jakobsson@ki.se

Group members

Marina Korotkova, docent, Senior scientist, marina.korotkova@ki.se

Louise Berg, docent, Senior lab manager, louise.berg@ki.se

Julia Steinmetz Späh, PhD, Postdoc, julia.steinmetzspah@ki.se

Janika Welzel, MSc, PhD student, janika.welzel@ki.se

Jianyang Liu, MSc, PhD student, jianyang.liu@ki.se

Karin Larsson, PhD, Senior scientist, karin.larsson@ki.se

Ahlem Zaghmi, PhD, Postdoc, ahlem.zaghmi@ki.se

Iro Chaitoglou, MSc, Lab technician, iro.chaitoglou@ki.se

Louisa Brieskorn, MSc, Lab technician, louisa.brieskorn@ki.se

Liyan Mei, MSc, Visiting scientist, liyan.mei@ki.se

Erdem Aybay, MSc, PhD student, erdem.aybay@ki.se

Sanjay Boddul, PhD, Senior scientist, sanjaykumar.boddul@ki.se

Sabreen Alabbasi, MSc, lab technician, sabreen.alabbasi@ki.se

Helena Idborg, PhD, Senior scientist, helena.idborg@ki.se

Selected publications

About CMM

The Center for Molecular Medicine (CMM) is a foundation instituted by the Stockholm County Council (Region Stockholm). CMM is at the heart of a close partnership with the Karolinska University Hospital and Karolinska Institutet, fueling advancements in biomedical and clinical research.


Center for Molecular Medicine Foundation, org. nr. 815201-3689

Karolinska University Hospital L8:05

Visionsgatan 18

171 76 Stockholm, Sweden


Karolinska institutet
Karolinska universitetssjukhuset