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New study shows that Proprotein Convertase 6 plays a key role in vascular disease

New study shows that Proprotein Convertase 6 plays a key role in vascular disease

In a new study published in Circulation Research, researchers at CMM show that the enzyme PCSK6, the proprotein convert subtilisin / kexin 6, plays a key role in vascular disease. The findings give hope that PCSK6 may become a future target molecule for the development of anti-vascular disease drugs.

Unstable atherosclerosis causes myocardial infarction and stroke, but detailed knowledge is lacking about the molecular processes that make atherosclerotic plaques unstable. 

In a study from 2013 (Perisic L et al)1, researchers from the Vascular Surgery Group showed that PCSK6, proprotein convertase subtilisin/kexin 6 was one of the most enriched molecules in atherosclerotic plaques from patients with unstable atherosclerosis in the carotid artery.

In a new study published in Circulation Research (Rykaczewska U, Suur BE, Röhl S et al)2, the group has studied in detail the importance of PCSK6 in human vascular disease and demonstrated how this enzyme regulates the function of smooth muscle cells and structural remodelling of the vessel wall in various vascular diseases. The findings, which are based on several large patient cohorts, but also experimental cell culture studies and animal experiments, give hope that PCSK6 can become a future target molecule for the development of therapies for vascular disease. The latter can be seen in the light of the success of drugs against PCSK9, a related enzyme, which in recent years has been targeted for the treatment of high blood cholesterol and cardiovascular disease. The study was conducted in a broad international collaboration with over 5000 patients and was led by Professor Ulf Hedin and Assistant Professor Ljubica Matic

Read more about the study on Karolinska Institutets website here

 

 

1.

Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis, Perisic L et al., Arterioscl Thromb Vasc Biol. 2013, October; 33 (10): 2432-43

 

2. 

PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.Rykaczewska U, Suur BE, Röhl S et al., Circ Res 2020 Jan 2 doi:10.1161/CIRCRESAHA.119.316063

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