Selected publications

Selected publications


Carlström KE, Zhu K, Ewing E, Krabbendam IE, Harris RA, Mendanha Falcão A, Jagodic M, Castelo-Branco G, Piehl F. Glutathione S-transferase 4α is a key regulator of oligodendrocyte differentiation and remyelination in models of multiple sclerosis, by reducing Fas/Caspase-8 pathway activity. Nature Communications 2020 PubMed

Tsuji S, di Martino E, Mukai T, Tsuji S, Murakami T, Harris RA, Blomgren K, Åden U. Aggravated brain injury in microglia depleted male mice after neonatal hypoxic ischemia. Journal of Neuroinflammation 2020 17:111 PubMed

Zhu K, Pieber M, Blomgren K, Zhang X-M, Harris RA, Lund H. Absence of microglia or presence of peripherally derived macrophages do not affect tau pathology in young or old hTau mice. Glia 2020 68:1466-1478 PubMed

N'diaye M, Brauner S, Flytzani S, Kular L, Warnecke A, Adzemovic MZ, Piket E, Min JH, Edwards W, Mela F, Choi HY, Magg V, James T, Linden M, Reichardt HM, Daws MR, van Horssen J, Kockum I, Harris RA, Olsson T, Guerreiro-Cacais AO, Jagodic M. C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation. Journal of Clinical Investigation 2020 130:838–852 PubMed



Di Martino E, Bocchetta E, Tsujia S, Mukai T, Harris RA, Blomgren K, Ådén U. Defining a therapeutic window for neuroprotection and glia modulation by caffeine during neonatal hypoxia-ischemia. Molecular Neurobiology 2019 57:2194–2205 PubMed

Gromark C, Harris RA, Wickström R, Horne AC, Silverberg M, Serlachius E, Mataix-Cols D. Establishing a Pediatric Acute-onset Neuropsychiatric Syndrome Clinic: Baseline clinical features of the PANS cohort at Karolinska Institutet. Journal of Child and Adolescent Psychopharmacology 29:625-633 PubMed

Tang Q, Gheorghe KR, Zhang X-M, Lindroos E, Helene Alexanderson MLT, Wick C, Bruton M, Fernandes-Cerqueira C, Harris RA, Nennesmo I, Lundberg IE. Features of repeated muscle biopsies and phenotypes of monocytes in paired blood samples and clinical long-term response to treatment in patients with idiopathic inflammatory myopathy – a pilot study. In Press, Clinical and Experimental Rheumatology PubMed

Lippitz BE, Harris RA. Translational Concept of Immuno-Radiobiology. Radiotherapy and Oncology 2019 140:116-124 PubMed

Yang T, Xu G, Newton PT, Chagin AS, Mkrtchian S, Carlström M, Zhang X-M, Harris RA, Cooter M, Berger M, Maddipati KR, Akassoglou K, Terrando N. Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders. British Journal of Anaesthesia 2018 122:350-360 PubMed

Zhu K, Sun J, Kang Z, Zouab Z, Wu X, Wanga Y, Wu G, Harris RA, Wang J. Repurposing of omeprazole for oligodendrocyte differentiation and remyelination. Brain Research 2019 1710:33-42 PubMed

Yang T, Xu G, Newton PT, Chagin AS, Mkrtchian S, Carlström M, Zhang X-M, Harris RA, Cooter M, Berger M, Maddipati KR, Akassoglou K, Terrando N. Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders. British Journal of Anaesthesia 2018 122:350-360 PubMed



Lund H, Pieber M, Parsa R, Han J, Grommisch D, Ewing E, Kular L, Needhamsen M, Butovsky O, Jagodic M, Zhang X-M, Harris RA: Competitive repopulation of an empty microglial niche gives rise to functionally distinct subsets of microglia-like cells. 2018 Nature Communications 9:4845  PubMed

Han J, Zhu K, Zhang X-M, Harris RA. Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders. 2018 Glia 67:217-231 PubMed

Wallmann T, Zhang X-M, Wallerius M, Bolin S, Joly A-L, Sobocki C, Leiss L, Jiang Y, Bergh J, Andersson J, Holland EC, Enger PØ, Swartling FJ, Uhrbom L, Miletic H, Harris RA, Rolny C. Microglia induce PDGFRB expression in glioma cells to enhance their migratory capacity. 2018 iScience, 9:71-83 PubMed

Obeed OAA, Vaali-Mohamed M-A , Alkhayal KA, Traiki TAB, Zubaidi AM, Arafah M, Harris RA, Khan Z, Hamadien Abdulla M. Interleukin 17 and colorectal cancer risk in Middle East: Gene polymorphisms and expression. 2018 Cancer Management and Research 10:2653–2661  PubMed

Lund H, Pieber M, Parsa R, Grommisch D, Ewing E, Kular L, Han J, Zhu K, Nijsen J, Hedlund E, Needhamsen M, Ruhrmann S, Ortlieb Guerreiro Cacais A, Berglund R, Forteza MJ, Ketelhuth DFJ, Butovsky O, Jagodic M, Zhang X-M, Harris RA: Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling. 2018 Nature Immunology 19:1-7 PubMed



Warnecke A, Abele S, Musunuri S, Bergquist J, Harris RA. Scavenger Receptor A mediates the clearance and immunological screening of MDA-modified antigen by M2 type macrophages. 2017 NeuroMolecular Medicine  9:463-479  PubMed

Sackmann V, Ansell A, Sackmann C, Lund H, Harris RA, Hallbeck M, Nilsberth C. Anti-inflammatory (M2) macrophage media reduce transmission of oligomeric amyloid-beta in differentiated SH-SY5Y cells 2017 Neurobiology of Aging 60:173-182 PubMed

Lund H, Pieber M, Harris RA. Lessons learned about neurodegeneration from microglia and monocyte depletion studies. 2017 Frontiers in Aging Neuroscience 9:234 PubMed

Barnett JV, Harris RA, Mulvany MJ. A comparison of best practices for doctoral training in the European and North American continents. 2017 FEBS Open Bio  7:1444-1452 PubMed

Han J, Harris RA, Zhang X-M. An updated assessment of microglia depletion: current concepts and future directions. 2017 Molecular Brain 10:25  PubMed

Yang T, Zhang X-M, Tarnawski L, Peleli M, Zhuge Z, Terrando N, Harris RA, Olofsson P, Larsson E, Persson AEG, Lundberg JO, Weitzberg E, Carlstrom M. Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. 2017 Redox Biology 13:320-330  PubMed



Warnecke A, Musunuri S, N’diaye M, Sandalova T, Achour A, Bergquist J, Harris RA. Nitration of MOG diminishes its encephalitogenicity depending on MHC haplotype. J Neuroimmunology 2016 303:1-12 PubMed

Han W, Umekawa T, Zhou K, Zhang X-M, Harris RA, Zhu C, Blomgren K. Cranial irradiation induces transient microglial response with specific gene expression signature and immune profile. OncoTarget 2016 7:82305-82323 PubMed

Hägglöf T, Sedimbi KS, Yates JL, Parsa R, Hauff B, Harris RA, Leadbetter EA, Karlsson MCI. Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses. Nature Immunology 17:1407-1414 PubMed

Parsa R, Lund H, Tosevski I, Zhang XM, Malipiero U, Beckervordersandforth J, Merkler D, Prinz M, Gyllenberg A, James T, Warnecke A, Hillert J, Alfredsson L, Kockum I, Olsson T, Fontana A, Suter T, Harris RA. TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells. Glia 2016 64:1925-37. PubMed

Radenkovic M, Åkesson C, Arvastsson J, Lynch K, Lernmark Å, Harris RA, Agardh CD, Cilio C. Altered regulatory T-cell phenotype in latent autoimmune diabetes of the adults (LADA). Clinical and Experimental Immunology 2016 186:46-56 PubMed

Tarasova NK, Ytterberg AJ, Lundberg K, Zhang XM, Harris RA, Zubarev RA. Establishing a proteomics-based monocyte assay to assess differential innate immune activation responses. J Proteome Res.2016 15:2337-45 PubMed

Parsa R, Lund L, Georgoudaki A-M, Zhang X-M, Ortlieb Guerreiro-Cacais A, Grommisch D, Warnecke A, Croxford AL, Jagodic M, Becher B, Karlsson MCI, Harris RA. BAFF-secreting neutrophils drive plasma cell genesis during emergency granulopoiesis. J Exp Med 2016 213:1537-53 PubMed

Georgoudaki A-M, Prokopec K, Hellqvist E, Boura V, Östling J, Sohn S, Harris RA, Rantalainen M, Klevebring D, Sund M, Fuxe J, Rolny C, Li F, Ravetch, Karlsson MCI. Reprogramming tumor associated macrophages by antibody targeting inhibits cancer progression and metastasis. Cell Reports 2016 15:2000-2011 PubMed

Schmidt A, Zhang X-M, Joshi RN, Iqbal S, Wahlund C, Gabrielsson S, Harris RA*, Tegnér J*. Human macrophages induce CD4+Foxp3+ regulatory T cells via binding and re-release of TGF-β. Immunol & Cell Biol 2016 PubMed

Yao G, Wang P, Luo XD, Yu TM, Harris RA, Zhang XM. Meta-analysis of association betweenHelicobacter pylori infection and multiple sclerosis. Neurosci Lett. 2016;620:1-7 PubMed

N’diaye M, Warnecke A, Flytzani S, Abdelmagid N, Ruhrmann S, Olsson T, Jagodic M*, Harris RA*, Guerreiro-Cacais AO*. Rat bone marrow-derived dendritic cells generated with GM-CSF/IL-4 or FLT3L exhibit distinct phenotypical and functional characteristics. J Leukoc Biol. 2016;99:437-46. PubMed

Mills CD, Lenz LL, Harris RA. A breakthrough: Macrophage-directed cancer immunotherapy. Cancer Research 2016;76:3 PubMed

Lippitz B, Harris RA. Cytokine Patterns in Cancer Patients: A Review of the Correlation Between Interleukin 6 and Prognosis. OncoImmunology 2016 11;5:e1093722 PubMed



Mills CD, Harris RA, Ley K. Macrophage Polarization: Decisions That Affect Health. Clin Cell Immunol.2015;6:5 pii: 364. PubMed

Tarasova N., Ytterberg A., Lundberg K, Harris RA, Zubarev R. Proteomics reveals synergetic effects of activation and attachment in monocyte differentiation into macrophages. J Proteome Research 2015;14:3940−3947 PubMed

Yang T, Gao X, Sandberg M, Zollbrecht C, Zhang X-M, Hezel M, Liu M, Peleli M, Lai EN, Harris RA, Persson AE, Fredholm BB, Jansson L, Carlström M. Abrogation of adenosine A1 receptor signaling improves metabolic regulation in aging and obesity. Diabetologia 2015 58:1610-20 PubMed

Wang J, Cao Z, Zhang XM, Nakamura M, Sun M, Hartman J, Harris RA, Sun Y, Cao Y. Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumour development. Cancer Res. 2015 Jan 15;75(2):306-15 Pubmed


- 2014

Zhang X-M., Lund H., Mia S., Parsa R., Harris RA. Adoptive transfer of cytokine-induced immunomodulatory adult microglia attenuates experimental autoimmune encephalomyelitis in DBA/1 mice. Glia. 2014 ;62(5):804-17 Pubmed

Scheffel J, Regen T, Van Rossum D, Seifert S, Ribes S, Nau R, Parsa R, Harris RA, Boddeke HW, Chuang HN, Pukrop T, Wessels JT, Jürgens T, Merkler D, Brück W, Schnaars M, Simons M, Kettenmann H, Hanisch UK. Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia. Glia. 2012;60:1930-43 Pubmed

Fransson M., Piras E., Burman J., Nilsson B., Essand M., Lu B., Harris RA., Magnusson PU., Brittebo E., Loskog AS. CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery. J Neuroinflammation. 2012; 30;9:112 Pubmed

Parsa R., Andresen P., Gillett A., Mia S., Zhang X-M., Mayans S., Holmberg D., Harris RA. Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice. Diabetes 2012 61:2881-92. 28. Pubmed

Harris RA & Amor S. Sweet and Sour – Oxidative and carbonyl stress in neurological disorders. CNS Neurol Disord Drug Targets 2011; Pubmed  

Gillett A, Marta M, Jin T, Tuncel J, Leclerc P, Nohra R, Lange S, Holmdahl R, Olsson T, Harris RA, Jagodic M. TNF production in macrophages is genetically determined and regulates inflammatory diseases. J Immunol 2010;185;442-450. Pubmed

Eriksson F, Tsagozis P, Lundberg K, Parsa R, Mangsbo SM, Persson MA, Harris RA, Pisa P. Tumor-specific bacteriophages induce tumor destruction through activation of tumor-associated macrophages. J Immunol 2009;182:3105-3111. Pubmed

Stromnes IM, Cerretti LM, Liggitt D, Harris RA, Goverman JM. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat Med 2008;14:337-342. Pubmed

Andersson A, Covacu R, Sunnemark D, Danilov AI, Dal Bianco A, Khademi M, Wallstrom E, Lobell A, Brundin L, Lassmann H, Harris RA. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. J Leukoc Biol 2008;84:1248-1255. Pubmed