Asset Publisher

Antibodies stabilize plaque in arteries

Antibodies stabilize plaque in arteries

A recent study, led by researchers at CMM, shows that type IgG antibodies play an unexpected role in atherosclerosis. The researchers hope that the results will eventually lead to improved therapies.

The team behind the present study has studied how atherosclerotic plaque develops in mice that lack antibodies.

“We found that plaque formed in an antibody-free environment was unusually small,” says study leader Stephen Malin, senior researcher at Karolinska Institutet’s Department of Medicine in Solna. “But on closer inspection, we discovered that the plaque looked different and contained more lipid and fewer muscle cells than normal. This suggested that the plaque is unstable and more prone to rupturing, which also turned out to be the case.”

“It came as a huge surprise to us that antibodies can play such an important role in the formation of arterial plaque,” says Dr. Malin. “We now want to find out if it is some special type of IgG antibody that recognizes plaque components. If so, this could be a new way of mitigating atherosclerosis and hopefully reducing the number of deaths from cardiovascular disease.”

Stephen Malin and Monica Centa

Last author Stephen Malin and first author Monica Centa. Photo: Alessandro Gallina

 

The study Germinal center-derived antibodies promote atherosclerosis plaque size and stability was published in the scientific journal Circulation, 21 March 2019.

Read more at Karolinska Intitutet website.

NEWS

Simple blood test may help predict MS progression, study finds

Simple blood test may help predict MS progression, study finds Photo: Ali Manouchehrinia   A study led by the CMM researchers Ali Manouchehrinia (first...

Experimental study finds new substances with higher specificity and therapeutic potential in multiple sclerosis

Experimental study finds new substances with higher specificity and therapeutic potential in multiple sclerosis   Karl Carlström, photo Stefan Zimmerman   Karl...

Early exposure to cannabis boosts young brains' sensitivity to cocaine, rodent study shows

Early exposure to cannabis boosts young brains' sensitivity to cocaine, rodent study shows A study made by Philippe Melas from Karolinska Institutet together with colleagues at Columbia...

Grant to Eduardo Villablanca for studies of stem cell-mediated tissue regeneration in the intestine

Grant to Eduardo Villablanca for studies of stem cell-mediated tissue regeneration in the intestine Associate Professor Eduardo Villablanca, Group Leader at CMM, has received a Junior...

Anca Catrina, Wallenberg Clinical Scholar 2020

Anca Catrina, Wallenberg Clinical Scholar 2020 We congratulate our CMM researcher Professor Anca Catrina, Group Leader at Karolinska Institutet and senior physician, who has been appointed...

Junior Investigator Award to Carmen Gerlach

Junior Investigator Award to Carmen Gerlach Assistant Professor Carmen Gerlach, Team Leader at CMM, will receive funding during six years from the Swedish Cancer Society (Cancerfonden) for...

Proteins that protect against joint inflammation identified

Proteins that protect against joint inflammation identified " Endogenous proteins that play a vital part in allergies and parasitic infection can prevent the immune system from wrongly...

New study shows that Proprotein Convertase 6 plays a key role in vascular disease

New study shows that Proprotein Convertase 6 plays a key role in vascular disease In a new study published in Circulation Research, researchers at CMM show that the enzyme PCSK6, the...

Unexpected effect of MS drug

Unexpected effect of MS drug Karl Carlström and Fredrik Piehl Photo: Stefan Zimmerman   Researchers at CMM have studied the mechanism of action of a drug used to treat...

New findings about how Parkinson's disease develops

New findings about how Parkinson's disease develops A new study by researchers at CMM shows that the protein alpha-synuclein, which accumulates in patients with Parkinson’s disease, occurs...