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Molecular puzzle reveals unknown stages of fetal development

Molecular puzzle reveals unknown stages of fetal development

By applying gene analysis to individual cells from early mouse embryos, CMM researcher Qiaolin Deng and her team have discovered previously unknown cellular stages of fetal development from fertilized egg to living being.

Dr. Qiaolin Deng led the study which has revealed new details of the critical phase between the attachment of the embryo to the uterus and the formation of the first anatomical axis, at which point the embryonic cells begin their journey towards creating a body, with a front and a back.

“The study has revealed previously unknown details about what happens before the early embryo gains its first spatial orientation, and shown that the cells along the future head-tail axis have different differentiation potential,” says Dr. Deng to KI News.

Qiaolin Deng

Qiaolin Deng. Photo: private

 

The study Single-cell RNA-seq reveals cellular heterogeneity of pluripotency transition and X-chromosome dynamics during early mouse development is published in the scientific journal Cell Reports.

Read the full news story at Karolinska Institutet website.

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