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New method divides patients with ulcerative colitis in groups

New method divides patients with ulcerative colitis in groups

Researchers at CMM have found a way of using gene expression conserved across species to divide patients with the inflammatory bowel disease ulcerative colitis into two distinct groups. The researchers hope that the method can also be used to subdivide other autoimmune diseases.

Ulcerative colitis is an inflammatory bowel disease affecting the colon and rectum. It manifests itself differently in patients, and only 50 to 60 per cent respond to the treatment with so-called biological drugs.

There is therefore a need to divide patients into different groups so that new pharmaceutical targets can be identified and treatments tailored accordingly.

“We’ve managed to divide patients with ulcerative colitis into two molecularly distinct groups using a method that we believe can be used for other diseases too,” says the study’s corresponding author Eduardo Villablanca, associate professor at the Department of Medicine, Solna.

Eduardo Villablanca. Photo: Knut och Alice Wallenbergs Stiftelse, Magnus Bergström

 

The study ”Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification” was published in Nature Communications, online 28 juni 2019.

Read the full news story at Karolinska Institutet website.

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