Asset Publisher

Rare disease gives new insight into regulatory T-cell function

Rare disease gives new insight into regulatory T-cell function

An international study led by researchers at CMM provides new insights into the regulatory T cells’ role in protecting against autoimmune disease. By mapping the targets of the immune system in patients with the rare disease IPEX, they were able to show that regulatory T cells control immunotolerance in the gut.

The researchers took advantage of a method that makes it possible to examine the immune response against 9,000 proteins in parallel.

“Our study is the first large-scale assay of how the immune system attacks the organs of IPEX patients,” says first author Daniel Eriksson to KI News.

“We hope that our results will make it easier to diagnose patients with IPEX and monitor them during treatment,” says Nils Landegren, the study’s last author.

Daniel Eriksson and Nils Landegren. Photo: Fabian Sardh. 

The study The autoimmune targets in IPEX are dominated by gut epithelial proteins was published in Journal of Allergy and Clinical Immunology, online 23 April 2019.

Read more at Karolinska Institutet website.

NEWS

Unexpected effect of MS drug

Unexpected effect of MS drug Karl Carlström and Fredrik Piehl Photo: Stefan Zimmerman   Researchers at CMM have studied the mechanism of action of a drug used to treat...

New findings about how Parkinson's disease develops

New findings about how Parkinson's disease develops A new study by researchers at CMM shows that the protein alpha-synuclein, which accumulates in patients with Parkinson’s disease, occurs...

New method divides patients with ulcerative colitis in groups

New method divides patients with ulcerative colitis in groups Researchers at CMM have found a way of using gene expression conserved across species to divide patients with the inflammatory...

Rheumatoid arthritic pain could be caused by antibodies

Rheumatoid arthritic pain could be caused by antibodies In a recently published study, researchers at CMM has shown that antibodies that exist in the joints before the onset of rheumatoid...

Financial support from The Swedish Childhood Cancer Fund to Ann Nordgren for her research position

Financial support from The Swedish Childhood Cancer Fund to Ann Nordgren for her research position Research positions are awarded once a year by the Swedish Childhood Cancer Fund. In 2019,...

Rare disease gives new insight into regulatory T-cell function

Rare disease gives new insight into regulatory T-cell function An international study led by researchers at CMM provides new insights into the regulatory T cells’ role in protecting against...

Antibodies stabilize plaque in arteries

Antibodies stabilize plaque in arteries A recent study, led by researchers at CMM, shows that type IgG antibodies play an unexpected role in atherosclerosis. The researchers hope that...

Prestigious grant for research on autoimmunity

Prestigious grant for research on autoimmunity Professor Olle Kämpe is one of five appointed Wallenberg Clinical Scholars in 2019. He will receive SEK 15 million to study why the immune...

Molecular puzzle reveals unknown stages of fetal development

Molecular puzzle reveals unknown stages of fetal development By applying gene analysis to individual cells from early mouse embryos, CMM researcher Qiaolin Deng and her team have discovered...

New skeletal disease found and explained by CMM researchers

New skeletal disease found and explained by CMM researchers Researchers from the group Rare Diseases have discovered a new and rare skeletal disease. In a study published in the journal...