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Red blood cells cause cardiovascular injury in type 2 diabetes

Red blood cells cause cardiovascular injury in type 2 diabetes

Two new studies, conducted at CMM and KI, indicate that harmful effects of substances secreted from red blood cells could explain the increased risk of cardiovascular diseases in patients with type 2 diabetes.

“We found that healthy blood vessels exposed to red blood cells from patients with type 2 diabetes suffer damage to their to their innermost cell layers, the endothelial cells,” says Professor John Pernow, who led both studies.

“We also found that treatment that targeted arginase or oxygen-derived free radicals normalized red blood cell function, which meant that their harmful effect on cardiovascular function could be prevented.”

 

The studies are published in The Journal of the American College of Cardiology and JACC: Basic to Translational Science.

 

Read more at KI website.

 

John Pernow. Photo: Senthil Vasan Kandaswamy

 

 

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