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Selective targeting of catalytic and scaffolding function of protein kinases

CMM Extra Seminar

Start: 2019-09-24 - 15:00
End: 2019-09-24 - 16:00
Location: Rolf Luft Auditorium L1:00, Anna Steckséns gata 53

Selective targeting of catalytic and scaffolding function of protein kinases

Speaker: Stefan Knapp, Professor, Goethe University and SGC Frankfurt.

Host: Michael Sundström, PhD, Scientific Director of European Initiatives SGC & Karolinska Institutet

Prof Stefan Knapp studied Chemistry at the University of Marburg (Germany) and at the University of Illinois (USA). He did his PhD in protein crystallography at the Karolinska Institute in Stockholm (Sweden) (1996) and continued his career at the Karolinska Institute as a postdoctoral scientist (1996-1999). In 1999, he joined the Pharmacia Corporation as a principal research scientist in structural biology and biophysics. He left the company in 2004 to set up a research group at the Structural Genomics Consortium at Oxford University (SGC). From 2008 to 2015 he was a Professor of Structural Biology at the Nuffield Department of Clinical Medicine (NDM) at Oxford University (UK) and between 2012 and 2015 he was the Director for Chemical Biology at the Target Discovery Institute (TDI). He joined Frankfurt University (Germany) in 2015 as a Professor of Pharmaceutical Chemistry and the Buchmann Institute of Molecular Life Sciences. He remains associated to the SGC as a visiting Professor at Oxford and he is also adjunct Professor of the George Washington University. Since 2017 he is the CSO of the newly founded SGC node at the Goethe-University Frankfurt. His research interests are the rational design of selective inhibitors that target protein kinases as well as protein interactions modules that function as reader domains of the epigenetic code. 

 

Research Areas

My laboratory is interested in understanding molecular mechanisms that regulate protein function of key signalling molecules and how these mechanisms can be utilized for the development of highly selective and potent inhibitors (chemical probes). As a basis for this work we have generated a comprehensive set of high resolution crystal structures that cover most members of the protein family of interest. We are particularly interested in protein interactions module of the bromodomain family that specifically recognize ε-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. This effort generated several highly selective chemical probes targeting bromodomains. A second research focus is on protein kinases. Our laboratory has solved a comprehensive set of crystal structure of this large protein family offering the opportunity to understand molecular mechanisms of their regulation and developing new strategies for their selective targeting. We developed for example a number of highly selective inhibitors by exploring unusual binding modes and allosteric binding sites. A particular focus of the laboratory is also to understand structural mechanisms leading to slow binding kinetics as part of the K4DD consortium.

Read more about Stefan’s research here, and list of publications here.

Lägg till i kalenderAdd to Calendar 2019-09-24 15:00 2019-09-24 16:00 Europe/London Selective targeting of catalytic and scaffolding function of protein kinases Rolf Luft Auditorium L1:00, Anna Steckséns gata 53 Michael Sundström, PhD, Scientific Director of European Initiatives SGC & Karolinska Institutet

CALENDAR

Selective targeting of catalytic and scaffolding function of protein kinases

24 Sep

Speaker: Stefan Knapp, Professor, Goethe University and SGC Frankfurt.

Rolf Luft Auditorium L1:00, Anna Steckséns gata 53

Host: Michael Sundström, PhD, Scientific Director of European Initiatives SGC & Karolinska Institutet

Start: 15:00

Identification of relevant antigenic targets for successful liver cancer immunotherapy

26 Sep

Speaker: Anna Pasetto, Karolinska Institutet, Department of Laboratory Medicine (LABMED), Division of Clinical Microbiology

CMM Lecture Hall, L8:00, Visionsgatan 18

Host: Guro Gafvelin, Associate professor, Karolinska Institutet, Department of Clinical Neuroscience (CNS), CMM

Start: 12:00

Mechanisms of Resident T Cell Driven Tissue Responses During the Onset and Recurrence of Human Skin Inflammation

26 Sep

Speaker: Irène Gallais Sérézal

Rolf Luft Auditorium, L1:00, Anna Steckséns gata 53

Host:

Start: 13:30

Sexual Dimorphism in Autoimmunity- Novel Mechanisms

27 Sep

Speaker: Johann E. Gudjonsson MD. Ph.D., Associate Professor, Department of Dermatology, University of Michigan, USA

CMM Lecture Hall, L8:00, Visionsgatan 18, ground floor

Host: Liv Eidsmo, MD PhD, Associate Professor in Dermatology and Venereology, Department of Medicine Solna, Karolinska Institutet, Group Leader CMM

Start: 12:00

Tracking immunity in vivo: steady state and infection in mucosal tissues through multiphoton microscopy

10 Oct

Speaker: Researcher Rodrigo J. Gonzalez, Ph.D. Harvard Medical School Boston, USA

CMM Lecture Hall, L8:00, Visionsgatan 18

Host: Carmen Gerlach, Assistant Professor, Karolinska Institutet, Department of Medicine, Division of Rheumatology, Center for Molecular Medicine (CMM)

Start: 12.00

Title of the seminar will updated shortly

17 Oct

Speaker: The name of the speaker will be published shortly

CMM Lecture Hall, L8:00, Visionsgatan 18

Host: CMM Researcher Eduardo J. Villablanca, Associate Professor, Karolinska Institutet, Department of Medicine, Immunology and Allergy Unit

Start: 12:00

The title of the seminar will updated shortly

24 Oct

Speaker: The speakers name will be updated shortly

CMM Lecture Hall, L8:00, Visionsgatan 18

Host: CMM Researcher Maja Jagodic

Start: 12:00

Different "personalities" of human osteoclasts-- from clinical, translational and basic perspective

25 Oct

Speaker: Kent Soe, Associate professor, University of Southern Denmark, SDU

The location for this seminar will be updated shortly

Host: Camilla Svensson, PhD, Professor in molecular and cellular pain physiology, Karolinska Institutet, Department of Physiology and Pharmacology, Center for Molecular Medicine (CMM)

Start: 10:00

The title of the seminar will updated shortly

14 Nov

Speaker: Researcher Gonçalo Castelo-Branco

CMM Lecture Hall, L8:00, Visionsgatan 18

Host: CMM researcher Anna Fogdell-Hahn, Associate Professor, Karolinska Institutet, Department of Clinical Neuroscience, Clinical Neuroimmunology, Center for Molecular Medicine, CMM

Start: 12:00

The title of the seminar will updated shortly

21 Nov

Speaker: Researcher Joana F. Neves, King's Collage in London

CMM Lecture Hall, L8:00, Visionsgatan 18

Host: CMM Researcher Carmen Gerlach

Start: 12:00