Asset Publisher

Unexpected effect of MS drug

Unexpected effect of MS drug

Karl Carlström and Fredrik Piehl

Photo: Stefan Zimmerman

 

Researchers at CMM have studied the mechanism of action of a drug used to treat multiple sclerosis. The results, which are published in the journal Nature Communications, show that the drug affects cells in the innate immune system and that there is an unexpected link between therapeutic effect and an increase in the production of reactive oxygen species.

To read more, please click here 

 

Publication

”Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes”.

Karl E. Carlström, Ewoud Ewing, Mathias Granqvist, Alexandra Gyllenberg, Shahin Aeinehband, Sara Lind Enoksson, Antonio Checa, Tejaswi VS. Badam, Jesse Huang, David Gomez-Cabrero, Mika Gustafsson, Faiez Al Nimer, Craig E. Wheelock, Ingrid Kockum, Tomas Olsson, Maja Jagodic and Fredrik Piehl. 

Nature Communications, 12 July 2019. doi:10.1038/s41467-019-11139-3

 

NEWS

Unexpected effect of MS drug

Unexpected effect of MS drug
Unexpected effect of MS drug Karl Carlström and Fredrik Piehl Photo: Stefan Zimmerman   Researchers at CMM have studied the mechanism of action of a drug used to treat...

New findings about how Parkinson's disease develops

New findings about how Parkinson's disease develops
New findings about how Parkinson's disease develops A new study by researchers at CMM shows that the protein alpha-synuclein, which accumulates in patients with Parkinson’s disease, occurs...

New method divides patients with ulcerative colitis in groups

New method divides patients with ulcerative colitis in groups
New method divides patients with ulcerative colitis in groups Researchers at CMM have found a way of using gene expression conserved across species to divide patients with the inflammatory...

Rheumatoid arthritic pain could be caused by antibodies

Rheumatoid arthritic pain could be caused by antibodies
Rheumatoid arthritic pain could be caused by antibodies In a recently published study, researchers at CMM has shown that antibodies that exist in the joints before the onset of rheumatoid...

Financial support from The Swedish Childhood Cancer Fund to Ann Nordgren for her research position

Financial support from The Swedish Childhood Cancer Fund to Ann Nordgren for her research position
Financial support from The Swedish Childhood Cancer Fund to Ann Nordgren for her research position Research positions are awarded once a year by the Swedish Childhood Cancer Fund. In 2019,...

Rare disease gives new insight into regulatory T-cell function

Rare disease gives new insight into regulatory T-cell function
Rare disease gives new insight into regulatory T-cell function An international study led by researchers at CMM provides new insights into the regulatory T cells’ role in protecting against...

Antibodies stabilize plaque in arteries

Antibodies stabilize plaque in arteries
Antibodies stabilize plaque in arteries A recent study, led by researchers at CMM, shows that type IgG antibodies play an unexpected role in atherosclerosis. The researchers hope that...

Prestigious grant for research on autoimmunity

Prestigious grant for research on autoimmunity
Prestigious grant for research on autoimmunity Professor Olle Kämpe is one of five appointed Wallenberg Clinical Scholars in 2019. He will receive SEK 15 million to study why the immune...

Molecular puzzle reveals unknown stages of fetal development

Molecular puzzle reveals unknown stages of fetal development
Molecular puzzle reveals unknown stages of fetal development By applying gene analysis to individual cells from early mouse embryos, CMM researcher Qiaolin Deng and her team have discovered...

New skeletal disease found and explained by CMM researchers

New skeletal disease found and explained by CMM researchers
New skeletal disease found and explained by CMM researchers Researchers from the group Rare Diseases have discovered a new and rare skeletal disease. In a study published in the journal...