Unexpected effect of MS drug

Karl Carlström and Fredrik Piehl

Photo: Stefan Zimmerman

Researchers at CMM have studied the mechanism of action of a drug used to treat multiple sclerosis. The results, which are published in the journal Nature Communications, show that the drug affects cells in the innate immune system and that there is an unexpected link between therapeutic effect and an increase in the production of reactive oxygen species.

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Publication

”Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes”.

Karl E. Carlström, Ewoud Ewing, Mathias Granqvist, Alexandra Gyllenberg, Shahin Aeinehband, Sara Lind Enoksson, Antonio Checa, Tejaswi VS. Badam, Jesse Huang, David Gomez-Cabrero, Mika Gustafsson, Faiez Al Nimer, Craig E. Wheelock, Ingrid Kockum, Tomas Olsson, Maja Jagodic and Fredrik Piehl. 

Nature Communications, 12 July 2019. doi:10.1038/s41467-019-11139-3