Alexander Espinosa

Alexander Espinosa

Interferons constitute a family of cytokine we critical roles in the defense against pathogens, but that also are implicated in autoimmune diseases and cancer. Interferons tightly regulate the expression of a large number of genes, with diverse cellular functions. We investigate the roles of interferon-regulated genes (IRGs) in autoimmune disease and in cancer. By isolating discrete immune cell population from patients and controls followed by gene expression analyses, we obtain a cell-specific map of IRG expression. The function of identified IRGs are investigated both in vitro, using techniques such as lentiviral CRISPR/Cas9 and shRNA, and in vivo using genetically modified mice and xenograft cancer mouse models. To expand the understanding of IRGs we chart the protein interactomes of selected IRGs in immune cells and in cancer cells using proxeome proteomics (e.g. BioID). Furthermore, we use genome-wide CRISPR/Cas9 libraries in cancer cells to identify genes involved in metastasis and drug responses. We aim to identify druggable IRGs that are involved in the pathogenic mechanisms of autoimmune diseases and cancer.

 

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Bank: SEB, Stockholm, Sweden
Account No. 5201-11 370 12
Iban-number: SE16 5000 0000 0520 1113 7012
Bic-code (the bank´s electronic address): ESSESESS
Account holder: Center for Molecular Medicine Foundation
L8:05, Karolinska University Hospital
171 76 Stockholm, Sweden

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Team leader

Alexander Espinosa

E-mail

alexander.espinosa@ki.se

Job title

Senior researcher

House

L8:03