Clinical Neuroimmunology

Clinical Neuroimmunology

Part of our research focus is to understand the disease mechanism behind the autoimmune reaction in MS and a possible viral etiology. Our hypothesis is that specific autoimmunity is triggered by immune response against host proteins incorporated into viral particles. We are therefore interested in common viruses that can establish latency and reactivate within the central nervous system and the myelin producing oligodendrocytes. Our current candidate virus is human herpesvirus 6 (HHV-6). We have shown that HHV-6B induce epigenetic modifications of the host cells during infection and that most of these are within the telomeric region of the chromosome and correlates with integration of the virus into the chromosome. These findings opens up for alternative pathways for treatment by targeting epigenetic pathways that might be essential for viral propagation. We have also found that MS patients have a higher production of antibodies against HHV-6A, but not the HHV-6B, immediate early protein sequences, especially at younger age.
 

Another research focus is the development and consequences of anti-drug antibodies (ADA). Immune reaction against human proteins can be triggered by repetitive injections and when human proteins are used as drugs this can cause a problem. We investigate response to treatment in chronic inflammatory diseases with a special focus on antibody formation against immunomodulatory drugs and we run routine analysis to determine these anti-drug antibody responses. Serum samples can be sent to our laboratory for analysis of anti-drug antibodies in MS patients treated with interferon beta and natalizumab (Tysabri). We have from 2017 assay for antibodies against rituximab (Mabthera) and a method called PandA to break up immune complexes between infliximab and anti-infliximab ADA. If you are interested in these tests, please contact us for further discussion. Please visit this webpage for more information: http://ki.se/en/cns/the-laboratory-for-analysis-of-neutralizing-antibodies

Donations

Donations

   If you would like to support this area of research

   you could do that by using Swish transfer. 

  Our Swish number is 123-245 79 76

 

Always state the name of group leader in order for us to allocate the gift properly. 

Or you can also use the following accounts:

BG: 628-4418
PG: 514114-8

Always state the name of group leader in order for us to allocate the gift properly. 

If you are outside of Sweden, please use the following information:

Bank: SEB, Stockholm, Sweden
Account No. 5201-11 370 12
Iban-number: SE16 5000 0000 0520 1113 7012
Bic-code (the bank´s electronic address): ESSESESS
Account holder: Center for Molecular Medicine Foundation
L8:05, Karolinska University Hospital
171 76 Stockholm, Sweden

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Group leader

Anna Fogdell-Hahn

E-mail

anna.fogdell-hahn@ki.se

Job title

Associate Professor

House

L8:00

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Research

Infection and inflammation, Microbiology, Neuroscience

Disease

Epilepsia, Rheumatoid arthritis

Competence/titles

Autoimmunity, Cell culture, Central nervous system, Clinical trials, Cohort study, Immunohistochemistry, Intervention/therapy, Microscopy, Molecular, Neurodegeneration, Neuroinflammation, Neurology, Register research, Skin, Virology/virus