Autoantibodies and their role in inflammatory and autoimmune disease

Autoantibodies and their role in inflammatory and autoimmune disease

B-cells and antibodies are an essential part of the adaptive immune system and play important roles in protecting us from infectious threats. Yet, with the adaptive immune system comes also the risk of developing autoimmune disease and self-reactive IgG autoantibodies. In autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), the host immune system for unknown reasons recognize self-biomolecules as foreign causing, if untreated, devastating disease. Different diseases are characterized by different distinct disease-associated autoreactivities. RA is for example associated with the presence of circulating autoantibodies recognizing self-proteins post-translationally modified by citrullination. Yet, other types autoreactivities of IgM type may in contrast be very common also in health and play protective roles.

Our main research aim is to increase our understanding about how autoantibodies and autoreactive B cells contribute to the pathogenesis of human disease, with the future goal to develop new prognostic and therapeutic strategies. Our studies include investigations of both potentially pathogenic IgG reactivities as well as natural IgM reactivities with potentially immune-homeostatic capacities. We are using antibody engineering and high-throughput methodology to study the immunoglobulin diversity of autoreactive B cells in RA and SLE. We are in addition directly studying the immune activating properties of human monoclonal autoreactive antibody clones isolated from patients, and investigating how to modulate these functions in novel therapeutic approaches. We are especially interested in autoreactivity to post-translational modifications (PTMs) in different classes of autoantibodies.

 

 

 

Donations

Donations

If you would like to support this area of research you could do that by using Swish transfer. 
Our Swish number is: 1232457976

 

Always state the name of group leader in order for us to allocate the gift properly. 

 

Or you can use the following accounts:

BG 628-4418
PG 514114-8

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If you are outside of Sweden, please use the following information:

Bank: SEB, Stockholm, Sweden
Account No. 5201-11 370 12
Iban-number: SE16 5000 0000 0520 1113 7012
Bic-code (the bank´s electronic address): ESSESESS
Account holder: Center for Molecular Medicine Foundation
L8:05, Karolinska University Hospital
171 76 Stockholm, Sweden

 

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Team leader

Caroline Grönwall

E-mail

caroline.gronwall@ki.se

Job title

Associate Professor

House

L8:04