Cell and molecular immunology

Cell and molecular immunology

Cytomegalovirus (CMV) infects and is carried by 70-100% of the world’s population, but rarely gives symptoms in the healthy population. In immunosuppressed patients, such as organ or stem cell transplant patients, AIDS patients and neonates, CMV may cause very serious disease and even death.

 

CMV disease in these groups of patients has also high-lightened the role of the virus in the development of other diseases, in particular for vascular diseases, autoimmune diseases and possibly in certain types of cancer. We have developed new sensitive techniques for detection of CMV infection in tissues from patients with various autoimmune diseases, vascular diseases and cancers. We can now detect an active CMV infection in affected organs in a majority of these patients but not in healthy tissue from the same patients or in tissues from control patients.

 

We know that CMV is able control different cellular and immunological functions and may thereby precipitate disease development. Antiviral treatment strategies may therefore become useful to cure or control a variety of different diseases. Hence, our long-term goals are to further develop an understanding of how CMV is specifically involved in the development of different diseases, and to find new targets for treatment strategies.

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Group leader

Cecilia Söderberg-Nauclér

E-mail

cecilia.naucler@ki.se

Job title

Professor

House

U2 level 5

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Research

Cell, molecular and structural biology, Infection and inflammation

Disease

Cancer

Competence/titles

Angiogenesis, Antibodies, Apoptosis, Cell culture, Clinical trials, Drug development, Enzymes, Flow cytometry, Gene expression, Growth factor, Gynecology, Hormones, Hypoxia, Image analysis, Immunohistochemistry, Innate immunity, Intervention/therapy, Macrophage/Microglia/Monocryte/APC, Metabolism, Metastasis, Microscopy, Mitochondria, Molecular, Mutation, Natural killer cells, Neuroinflammation, Oxidative stress, Pathology, Protein expression, Proteins, Sequensing, Signal transduction