Autoimmune and inflammatory diseases – novel treatment strategies

Autoimmune and inflammatory diseases – novel treatment strategies

Using experimental systems and patient material we study the immune system with a specific interest related to inflammation, autoimmune disease and cancer immunotherapy.

 

A major part of the different projects in the lab relates to antibodies, neutrophils and T cells. We also spend a lot of effort into using CRISPR/Cas9 based custom screens as a discovery platform to understand complex biological processes and to identify novel drug targets. To facilitate the design of these screens, we have developed a software that we call Green Listed (link). A blog post describing our approach can be found at Addgene (link).

 

Currently several projects in the lab relates to our interest in signaling downstream of the IL-4 receptor (IL-4R). The basis for this interest was the unexpected finding that the expression of the IL-4R is essential for the activity of a drug (IVIG) used to treat patients with autoimmune disease, and that the expression of this receptor is highly regulated during inflammation (Anthony et al, 2011, Nature and Wermeling et al, 2013, PNAS).

 

Personal homepage | https://wermelinglab.com/

Youtube channel | https://www.youtube.com/channel/UCamAaFoUpC4ofoom_6fjbbQ

 

GruppChefPortlet

Team leader

Fredrik Wermeling

E-mail

fredrik.wermeling@ki.se

Job title

Assistant professor

House

L5:02