Pediatric rheumatology

Pediatric rheumatology

Our research aims at improving the knowledge regarding disease-causing mechanisms active during rheumatic diseases in children as well as in adults. The obtained knowledge forms a basis for the development of new, targeted anti-rheumatic therapy. We are especially interested in the group of self-molecules termed Alarmins. These are molecules with defined functions inside cells and a common function outside of cells; to alert the body to danger, cell death or cell stress due to infection or trauma, and induce an inflammatory response. A prototype alarmin is HMGB1 and we are studying its inflammation-inducing features, its role in rheumatic diseases and it’s potential as a target for new therapy. 

Our research programme can be divided into three related projects:

1. Studies of the proinflammatory functions of HMGB1 and their regulation

2. The role of HMGB1 in the immunopathogenesis of juvenile idiopathic arthritis (JIA). To perform these studies we have established a biobank (JABBA) of patient samples coupled with a quality register, Swedish Pediatric Rheumatology Registry, and are using molecular, cellular and in vitro/in vivo models.

Additionally we are also interested in studying the role of HMGB1 in other inflammatory conditions, including stroke and have an ongoing project (COUNTERSTROKE) to identify HMGB1 inhibitors that could be used in therapy.

Links:

COUNTERSTROKE EU FP7 project: http://www.counterstroke.net/

National research school in chronic inflammation   http://www.researchschool.se/

Donations

Donations

If you would like to support this area of research you could do that by using Swish transfer. 
Our Swish number is: 1232457976

 

Always state the name of group leader in order for us to allocate the gift properly. 

 

 

Or you can use the following accounts:

BG 628-4418
PG 514114-8

Always state the name of group leader in order for us to allocate the gift properly. 

If you are outside of Sweden, please use the following information:

Bank: SEB, Stockholm, Sweden
Account No. 5201-11 370 12
Iban-number: SE16 5000 0000 0520 1113 7012
Bic-code (the bank´s electronic address): ESSESESS
Account holder: Center for Molecular Medicine Foundation
L8:05, Karolinska University Hospital
171 76 Stockholm, Sweden

 

GruppChefPortlet

Group leader

Helena Erlandsson Harris

E-mail

helena.harris@ki.se

Job title

Professor

House

L8:03

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Research

Biomarkers, Circulation and respiration, Developmental biology and reproduction

Disease

Alcohol use disorder, Aneurysm, Articular cartilage repair, Bladder exstrophy, Brain tumors

Competence/titles

Addiction