Hypospadias

Hypospadias

Hypospadias, is a form of disturbed sex development in boys, when the meatus urethra is situated on the underside of the penis or in the perineum. The incidence in Sweden is 1 of 125 boys (Skarin et al 2014). The treatment is surgical. Hypospadia is a complex malformation arising due to an interaction between gene and environment. In our group we have studied monozygotic twins and also brothers to hypospadiac boys and could conclude that growth restriction is a factor in the pathogenesis of hypospadias, since it is the smallest of the twin/ brothers that get hypospadias. We have shown that the incidence in Sweden has increased to 1 in 125 boys and without a known cause.