Myositis research

Myositis research

IDIOPATHIC INFLAMMATORY MYOPATHY, MYOSITIS

Conditions associated with muscle inflammation are called inflammatory myopathies or myositis. Myositis is characterised mainly by muscle weakness, low muscle endurance and muscle pain.

OUR MAIN RESEARCH GOAL

The aim of our research is to gain increased knowledge of the causes of myositis and the mechanisms that lead to muscle weakness and also to the high incidence of inflammation in both skeletal muscle and lungs in order to provide patients with the best possible treatment. The basis for our research projects is longitudinal studies of patients with myositis. By combining clinical outcome measures with investigations of molecular expression in repeated muscle biopsies and in peripheral blood after different interventions, pharmacological therapies, and physical exercise we hope to increase the understanding of these diseases. Another aim is to understand why both the muscle and the lung becomes a target of the immune system for certain patients.

To accomplish our goals we combine clinical epidemiological research with molecular research on patient samples and we use experimental systems with muscle cell cultures. Our research is performed at the Center for Molecular Medicine (CMM), Karolinska Institutet. We follow patients at Karolinska University Hospital in a systematic way. In addition we are part of a Swedish Myositis Network (SweMyoNet) and of an international myositis network (MyoNet), www.myonet.eu, where Professor Ingrid E. Lundberg is PI and we contribute to the international myositis registry EuroMyositis, www.euromyositis.eu, in which more than 5000 patients with idiopathic inflammatory myopathies have been enrolled. We are also part of several international collaborations.

 

RESEARCH AREAS

  • Physical exercise studies
  • Longitudinal studies on clinical material to predict biomarkers for prognosis
  • Epidemiological studies to identify risk factors and comorbidities
  • New treatments are being tested in clinical trials
  • Pathogenic studies of new target molecules
  • The association between inflammation in muscles and lung
  • Malignancy and myositis
  • Specific autoantibodies and its importance
  • Cardiac studies
  • Genetic studies to identify risk factors

 

When contributing to our research activities, please state: Myositis research, Ingrid Lundberg.

 

 

Donations

Donations

   If you would like to support this area of research

   you could do that by using Swish transfer. 

  Our Swish number is 123-245 79 76

 

Always state the name of group/team leader in order for us to allocate the gift properly. 

Or you can also use the following accounts:

BG: 628-4418
PG: 514114-8

Always state the name of group/team leader in order for us to allocate the gift properly. 

If you are outside of Sweden, please use the following information:

Bank: SEB, Stockholm, Sweden
Account No. 5201-11 370 12
Iban-number: SE16 5000 0000 0520 1113 7012
Bic-code (the bank´s electronic address): ESSESESS
Account holder: Center for Molecular Medicine Foundation
L8:05, Karolinska University Hospital
171 76 Stockholm, Sweden

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Group leader

Ingrid Lundberg

E-mail

ingrid.lundberg@ki.se

Job title

Professor, senior physician

House

D2:01

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Research

Autoimmunity, Immunology, Inflammation

Disease

Myositis

Competence/titles

Autoimmunity, Immunohistochemistry, Microscopy