Mitochondria and endoplasmic reticulum in wound healing and rare skin conditions

Mitochondria and endoplasmic reticulum in wound healing and rare skin conditions

Dr Jakob Wikström has completed MD PhD as well as postdoctoral fellowship, and has recently established his own independent research team. His previous research has been focused on the role of mitochondria and endoplasmic reticulum in brown adipose tissue and pancreatic beta cells. Dr Wikström´s clinical specialty is dermato-venereology and the research is therefore directed on skin physiology and diseases.

Chronic leg ulcers cause great suffering in the elderly and consume 2 % of the health budget; yet the wound healing process is incompletely understood and today´s treatments are often inadequate. Mitochondria produce 90 % of the cell’s ATP, which is essential for most biological reactions including those involved in wound healing. To achieve this, mitochondria consume 90 % of the body´s oxygen. As wound healing has high energy requirements and the hypoxic nature of most wounds we are currently studying the role of mitochondria in the healing of chronic leg ulcers.

We also study the rare genetic conditions Darier´s disease and Hailey-Hailey´s disease, which are caused by disrupted calcium homeostasis in the endoplasmic reticulum and Golgi apparatus, respectively. Our aim is to gain better understanding of these diseases and to conduct a translational study in which we aim to develop improved therapies. Please contact Dr Jakob Wikström if you are a patient or healthy volunteer and would like to take part in this cutting edge research.

We are always looking for highly motivated scientists interested in joining our growing team.

Figure. Confocal microscopy image of mitochondria targeted with the fluorescent protein DsRed in a COS-7 cell.

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Team leader

Jakob Wikström

E-mail

jakob.wikstrom@ki.se

Job title

Assistant Professor

House

L8:02