Infection and immunology

Infection and immunology

The Broliden group works within the field of Infection-Immunology and is divided into teams headed by Professor Kristina Broliden, Professor Anna Färnert (malaria), Associate Professor Annelie Tjernlund (HIV), Doctor Lars Öhrmalm (infections in immunosuppressed patients), Doctor Christopher Sundling (vaccine immunology) and Doctor Muhammad Asghar (infections and ageing biology). The group is located within the CMM facility at the Karolinska University Hospital in Solna. All members of the group are affiliated to the Department of Medicine Solna, Karolinska Institutet and have a close association with the Department of Infectious Diseases, Karolinska University Hospital. The two main projects, malaria and HIV, are also closely associated to research institutes and universities in Kenya, Tanzania, USA and Canada and have attracted significant international funding.

 

Malaria

Malaria remains a major global health problem and new tools are needed to reduce malaria morbidity and mortality and eventually reach the goals of elimination. Development of an efficacious vaccine will require further understanding of how natural immunity to malaria is acquired and maintained. Our group is particularly interested in the importance of the extensive diversity of parasite antigens and mechanisms involved in the maintenance of protection. The molecular and sero-epidemiology of malaria is studied in a longitudinal population cohort in areas of varying transmission in Sub-Saharan Africa. Moreover, immune responses are studied in depth in a cohort of patients successfully treated for malaria and prospectively followed in Sweden, thus without risk of reinfection. Immunological memory is studied in the context of different infections and vaccines. In addition, we assess long term effects of malaria and other infections on the host including ageing biology. In a nation wide study of malaria in Sweden we investigate host factors, such as comorbidities, in relation to the risk of severe malaria, with aim to improve the clinical management and prevention of malaria.

 

Genital mucosal barriers against HIV infection

Environmental factors including hormonal contraceptive use, genital infections and seminal fluid itself affect the susceptibility to HIV infection as demonstrated in epidemiological and experimental studies. The molecular mechanisms behind these findings are however poorly defined. Our group aims to study how the human female genital tract is affected by these factors by assessing tissue samples and cervicovaginal secretions from large cohorts of Swedish and Kenyan women who are sexually exposed to HIV infection. Genital samples are defined by expression of epithelial junction proteins, distribution and density of HIV target cell receptors, presence and function of tissue-resident memory T cells as well as innate immune proteins by using imaging, tissue explants models and proteomics. By exploring some of the underlying mechanisms for a dysfunctional mucosal barrier we hope to contribute to the development of topical prophylactic compounds and to the prescription of optimal contraceptive methods to women.

Donations

Donations

If you would like to support this area of research you could do that by using Swish transfer. 
Our Swish number is: 1232457976

 

Always state the name of group leader in order for us to allocate the gift properly. 

 

 

Or you can use the following accounts:

BG 628-4418
PG 514114-8

Always state the name of group leader in order for us to allocate the gift properly. 

If you are outside of Sweden, please use the following information:

Bank: SEB, Stockholm, Sweden
Account No. 5201-11 370 12
Iban-number: SE16 5000 0000 0520 1113 7012
Bic-code (the bank´s electronic address): ESSESESS
Account holder: Center for Molecular Medicine Foundation
L8:05, Karolinska University Hospital
171 76 Stockholm, Sweden

 

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Group leader

Kristina Broliden

E-mail

kristina.broliden@ki.se

Job title

Professor

House

U2 level 7

GroupInformationPortlet

Research

Bioinformatics, Epidemiology, Infection and inflammation, Microbiology

Disease

Rheumatoid arthritis

Competence/titles

Cohort study, Flow cytometry, Image analysis, Immunohistochemistry, Mass spectometry, Omics, Proteomics