Ubiquitination in health and disease

Ubiquitination in health and disease

Our research aims to unveil the diverse roles of ubiquitination in preventing or driving diseases. Ubiquitination is an essential post-translational protein modification required to maintain cellular homeostasis, and alterations in ubiquitin-dependent pathways have been implicated in the pathogenesis of several human diseases. However, ubiquitination is a highly complex process and various aspects of the ubiquitin system are not yet fully understood. Gaining insight into the cellular and molecular mechanisms of ubiquitination, as well as into its physiological roles is therefore critical on the path to designing novel treatments. Our team applies innovative techniques to model diseases and alter the functions of ubiquitin-related genes in order to reveal the underlying molecular basis of disease pathogenesis, primarily focusing on cancer, immunity and metabolism. Our ultimate aim is to provide novel opportunities for the development of more effective and specific therapeutic strategies.

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Team leader

Magdalena Paolino

E-mail

magdalena.paolino@ki.se

Job title

Assistant professor

House

BioClinicum J8:20