Translational Neuropharmacology

Translational Neuropharmacology

Svenningsson Group_Exakt

Parkinson´s disease and Depression are common disorders with largely unknown etiologies. There is a need for disease-modifying therapies in these disease states. The Section of Translational Neuropharmacology studies these disease states at a molecular and cellular level both in preclinical models and in specimens from patients. The goal is to identify novel targets for improved diagnostics and pharmacological receptor-based treatments. It is important for receptors to be properly located in nerve cell to properly activate relevant intracellular signaling cascades. The laboratory studies the dynamics of the localization and functionality of receptors. A working hypothesis is that altered levels of receptors in a certain compartment of a nerve cell can underlie pathology. In that respect experiments are focused on identifying and study adaptor proteins and lipids which bind to receptors and regulate their localization and function. Biochemical, histological, pharmacological, molecular biological and behavioral techniques are being used in the laboratory.

Donations

Donations

   If you would like to support this area of research

   you could do that by using Swish transfer. 

  Our Swish number is 123-245 79 76

 

Always state the name of group leader in order for us to allocate the gift properly. 

Or you can also use the following accounts:

BG: 628-4418
PG: 514114-8

Always state the name of group leader in order for us to allocate the gift properly. 

If you are outside of Sweden, please use the following information:

Bank: SEB, Stockholm, Sweden
Account No. 5201-11 370 12
Iban-number: SE16 5000 0000 0520 1113 7012
Bic-code (the bank´s electronic address): ESSESESS
Account holder: Center for Molecular Medicine Foundation
L8:05, Karolinska University Hospital
171 76 Stockholm, Sweden

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Group leader

Per Svenningsson

E-mail

per.svenningsson@ki.se

Job title

Professor

House

BioClinicum J5:20

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Research

Neurology, Neuropharmacology, Neuroscience

Disease

ALS, Depression, Parkinson's disease

Competence/titles

Aging, Animal models, Behaviour, Biochemistry, Biomarkers, Cell culture, Central nervous system, Clinical gentics, Clinical trials, Depression, Drug development, Flow cytometry, Gene expression, Immunohistochemistry, Neurodegeneration, Neurosignalling, Signal transduction