We are primarily interested in understanding the pathogenesis of incurable, chronic disease states of the Central Nervous System, including ALS, MS, Alzheimer's disease and glioma brain tumors.
HOW CAN WE TREAT OR CURE THE DISEASES?
There is currently no cure for the diseases we study, and existing medications are only partly effective.
Our main interest is thus on developing new strategies to reduce or abrogate disease symptoms.
We focus on using the body’s own myeloid cells as a means of treating the same individual through ‘personalised cell therapy’ or by targeting these cells for immunomodulation.
Scientific Hypothesis addressed: Adoptive transfer of pre-activated myeloid cells will be an effective treatment for inflammatory/neurodegenerative disease states (LINK).
Scientific Hypothesis addressed: siRNA targeting of specific genes will be an effective treatment for inflammatory/neurodegenerative disease states.
Scientific Hypothesis addressed: Specific depletion of antigen-specific T cells that drive autoimmune diseases will be an effective treatment for autoimmune diseases with defined antigen specificities
Scientific Hypothesis addressed: Post-translational modification of self proteins makes them autoantigenic (LINK).