Selected publications

Selected publications

2017

Zhao X, Howell KA, He S, Brannan JM, Wec AZ, Davidson E, Turner HL, Chiang CI, Lei L, Fels JM, Vu H, Shulenin S, Turonis AN, Kuehne AI, Liu G, Ta M, Wang Y, Sundling C, Xiao Y, Spence JS, Doranz BJ, Holtsberg FW, Ward AB, Chandran K, Dye JM, Qiu X, Li Y, Aman MJ. Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability. Cell. 2017 May 18;169(5):891-904. 

Kräutler NJ, Suan D, Butt D, Bourne K, Hermes JR, Chan TD, Sundling C, Kaplan W, Schofield P, Jackson J, Basten A, Christ D, Brink R. Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells. J Exp Med. 2017 May 1;214(5):1259-1267. 

Suan D, Sundling C, Brink R. Plasma cell and memory B cell differentiation from the germinal center. Curr Opin Immunol. 2017 Apr;45:97-102

Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noel-Romas L, Grobler A, Westmacott G, Xie IY, Butler J, Mansoor L, McKinnon LR, Passmore JS, Abdool Karim Q, Abdool Karim SS, Burgener AD. Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women. Science 2017;356:938-45. 

Wyss K, Wångdahl A, Vesterlund M, Hammar U, Dashti S, Naucler P, Färnert A. Obesity and Diabetes as Risk Factors for Severe Plasmodium falciparum Malaria: Results from a Swedish Nationwide Study. Clin Infect Dis. 2017 May [Epub ahead of print] 

Portugal S, Tran TM, Ongoiba A, Bathily A, Li S, Doumbo S, Skinner J, Doumtabe D, Kone Y, Sangala J, Jain A, Davies DH, Hung C, Liang L, Ricklefs S, Homann MV, Felgner PL, Porcella SF, Färnert A, Doumbo OK, Kayentao K, Greenwood BM, Traore B, Crompton PD. Treatment of Chronic Asymptomatic Plasmodium falciparum Infection Does Not Increase the Risk of Clinical Malaria Upon Reinfection. Clin Infect Dis. 2017;64:645-653. 

Sondén K, Wyss K, Jovel I, Vieira da Silva A, Pohanka A, Asghar M, Homann MV, Gustafsson LL, Hellgren U, Färnert A. High Rate of Treatment Failures in Nonimmune Travelers Treated With Artemether-Lumefantrine for Uncomplicated Plasmodium falciparum Malaria in Sweden: Retrospective Comparative Analysis of Effectiveness and Case Series. Clin Infect Dis. 2017 64:199-206. 

Holmberg D, Franzén-Röhl E, Idro R, Opoka RO, Bangirana P, Sellgren CM, Wickström R, Färnert A, Schwieler L, Engberg G, John CC. Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria. Malar J. 2017;16:303. 

Murungi LM, Sondén K, Odera D, Oduor LB, Guleid F, Nkumama IN, Otiende M, Kangoye DT, Fegan G, Färnert A, Marsh K, Osier FH. Cord blood IgG and the risk of severe Plasmodium falciparum malaria in the first year of life. Int J Parasitol. 2017;47:153-162. 

Introini A, Boström S, Bradley F, Gibbs A, Glaessgen A, Tjernlund A, Broliden K. Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants.  PLoS Pathog 2017;13:e1006402

Cheuk S, Schlums H, Gallais Sérézal I, Martini E, Chiang SC, Marquardt N, Gibbs A, Detlofsson E, Introini A, Forkel M, Höög C, Tjernlund A, Michaelsson J, Folkersen L, Mjösberg J, Blomqvist L, Ehrström M, Ståhle M, Bryceson YT, Eidsmo L. CD49a expression defines tissue-resident CD8+ T cells poised for cytotoxic function in human skin. Immunity 2017;46:287-300. 

Birse KD, Romas LM, Guthrie BL, Nilsson P, Bosire R, Kiarie J, Farquahar C, Broliden K, Burgener AD. Genital injury signatures and microbiome alterations associated with depot medroxyprogesterone acetate usage and intravaginal drying practices. J Infect Dis 2017;215:590-98. 

 

2016

Lund JM*, Broliden K*, Pyra MN, Thomas KK, Donnell D, Irungu E, Muwonge TR, Mugo N, Manohar M, Jansson M, Mackelprang R, Marzinke M, Baeten J, Lingappa J. HIV-1-neutralizing IgA is detected in genital secretions of highly HIV-1 exposed seronegative women on oral pre-exposure prophylaxis. J Virol 2016;90:9855-61. *Shared first authors. 

Olofsson PS, Steinberg BE, Sobbi R, Cox MA, Ahmed MN, Oswald M, Szekeres F, Hanes WM, Introini A, Liu SF, Holodick NE, Rothstein TL, Lövdahl C, Chavan SS, Yang H, Pavlov VA, Broliden K, Andersson U, Diamond B, Miller EJ, Arner A, Gregersen PK, Backx PH, Mak TW, Tracey KJ. Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase. Nat Biotechnol 2016;34:1066-71. 

Öhrmalm L, Malinovschi A, Wong M, Levinson P, Janson C, Broliden K, Alving K. Presence of rhinovirus in the respiratory tract of adolescents and young adults with asthma without symptoms of infection. Respir Med 2016;115:1-6. 

Tjernlund A, Burgener A, Lindvall JM, Peng T, Zhu J, Ohrmalm L, Picker LJ, Broliden K, McElrath MJ, Corey L. In situ staining and laser capture microdissection of lymph node residing SIV gag-specific CD8+ T cells; a tool to interrogate a functional immune response ex vivo. PLoS One 2016;11:e0149907.

Gibbs A, Leeansyah E, Introini A, Paquin-Proulx D, Hasselrot K, Andersson E, Broliden K, Sandberg JK, Tjernlund A. MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation. Mucosal Immunol 2016;10:35-45. 

Asghar M, Palinauskas V, Zaghdoudi-Allan N, Valkiūnas G, Mukhin A, Platonova E, Färnert A, Bensch S, Hasselquist D. Parallel telomere shortening in multiple body tissues owing to malaria infection. Proc Biol Sci. 2016;283(1836). 

Yman V, White MT, Rono J, Arcà B, Osier FH, Troye-Blomberg M, Boström S, Ronca R, Rooth I, Färnert A. Antibody acquisition models: A new tool for serological surveillance of malaria transmission intensity. Sci Rep. 2016;6:19472

Jahnmatz P, Bengtsson T, Zuber B, Färnert A, Ahlborg N. An antigen-specific, four-color, B-cell FluoroSpot assay utilizing tagged antigens for detection. J Immunol Methods. 2016;433:23-30. 

Murungi LM, Sondén K, Llewellyn D, Rono J, Guleid F, Williams AR, Ogada E, Thairu A, Färnert A, Marsh K, Draper SJ, Osier FH. Targets and Mechanisms Associated with Protection from Severe Plasmodium falciparum Malaria in Kenyan Children. Infect Immun. 2016 ;84:950-63. 

Mwebaza N, Jerling M, Gustafsson LL, Silva AV, Pohanka A, Obua C, Waako P, Beck O, Homann MV, Färnert A, Hellgren U. Oil-Fortified Maize Porridge Increases Absorption of Lumefantrine in Children with Uncomplicated Falciparum Malaria. Basic Clin Pharmacol Toxicol. 2016 Nov 24. 

Martinez P, Pramanik L, Sundling C, Hultenby K, Wretenberg P, Spångberg M, Karlsson Hedestam GB. CD138 and CD31 double-positive cells comprise the functional antibody-secreting plasma cell compartment in primate bone marrow. Front Immunol. 2016 Jun 27;7:242. 

Wang Y, Sundling C, Wilson R, O’Dell S, Chen Y, Dai K, Phad G, Zhu J, Xiao Y, Mascola  JR, Karlsson Hedestam GB, Wyatt RT, Li Y. High resolution longitudinal study of HIV-1 vaccine-elicited B cell responses against the virus primary receptor binding site reveals affinity maturation and clonal persistence. J Immunol. 2016 May 1;196(9):3729-43. Highlighted in “In this issue” 

Dai K, Kahn S, He L, Ingale J, Sundling C, Guenaga J, O’Dell S, Phad G, Li Y, Mascola JR, Zhu J, Karlsson Hedestam GB, Wyatt RT. HIV-1 vaccine-elicited antibodies reverted to their inferred germline reveal associations between in vitro binding affinity and in vivo activation. Sci Rep 2016 Feb 16;6:20987. 

Christopher Sundling and Kerrie Sandgren. CTI special feature on innate immune responses and vaccine design. Clin Trans Immunology 2016. 5(8):e96.