Selected publications

Selected publications

  • Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis. Gisterå A, Hermansson A, Strodthoff D, Klement ML, Hedin U, Fredrikson GN, Nilsson J, Hansson GK, Ketelhuth DF. J Intern Med. 2017 Apr;281(4):383-397.
  • Hypercholesterolemia Induces Differentiation of Regulatory T Cells in the Liver. Mailer RKW, Gisterå A, Polyzos KA, Ketelhuth DFJ, Hansson GK. Circ Res. 2017 May 26;120(11):1740-1753.
  • Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice. Polyzos KA, Ovchinnikova O, Berg M, Baumgartner R, Agardh H, Pirault J, Gisterå A, Assinger A, Laguna-Fernandez A, Bäck M, Hansson GK, Ketelhuth DF. Cardiovasc Res. 2015 May 1;106(2):295-302.
  • The leukotriene B4 receptor (BLT) antagonist BIIL284 decreases atherosclerosis in ApoE-/- mice. Ketelhuth DF, Hermansson A, Hlawaty H, Letourneur D, Yan ZQ, Bäck M. Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt A):105-9.
  • Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response. Grasset EK, Duhlin A, Agardh HE, Ovchinnikova O, Hägglöf T, Forsell MN, Paulsson-Berne G, Hansson GK, Ketelhuth DF, Karlsson MC. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2030-8.
  • Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) triggers platelet activation and boosts platelet-leukocyte proinflammatory responses. Assinger A, Wang Y, Butler LM, Hansson GK, Yan ZQ, Söderberg-Nauclér C, Ketelhuth DF. Thromb Haemost. 2014 Aug;
  • Transforming growth factor-β signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway. Gisterå A, Robertson AK, Andersson J, Ketelhuth DF, Ovchinnikova O, Nilsson SK, Lundberg AM, Li MO, Flavell RA, Hansson GK. Sci Transl Med. 2013 Jul 31;5(196):196ra100.
  • Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis. Lundberg AM, Ketelhuth DF, Johansson ME, Gerdes N, Liu S, Yamamoto M, Akira S, Hansson GK. Cardiovasc Res. 2013 Jul 15;99(2):364-73.
  • Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. Klingenberg R, Gerdes N, Badeau RM, Gisterå A, Strodthoff D, Ketelhuth DF, Lundberg AM, Rudling M, Nilsson SK, Olivecrona G, Zoller S, Lohmann C, Lüscher TF, Jauhiainen M, Sparwasser T, Hansson GK. J Clin Invest. 2013 Mar;123(3):1323-34.
  • The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice.
  • Zhang L, Ovchinnikova O, Jönsson A, Lundberg AM, Berg M, Hansson GK, Ketelhuth DF. Eur Heart J. 2012 Aug;33(16):2025-34.
  • Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses. Ketelhuth DF, Rios FJ, Wang Y, Liu H, Johansson ME, Fredrikson GN, Hedin U, Gidlund M, Nilsson J, Hansson GK, Yan ZQ. Circulation. 2011 Nov 29;124(22):2433-43, 1-7.
  • Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice. Hermansson A, Johansson DK, Ketelhuth DF, Andersson J, Zhou X, Hansson GK. Circulation. 2011 Mar 15;123(10):1083-91.
  • Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis. Hermansson A, Ketelhuth DF, Strodthoff D, Wurm M, Hansson EM, Nicoletti A, Paulsson-Berne G, Hansson GK. J Exp Med. 2010 May 10;207(5):1081-93.

 

Review articles

  • The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis. Baumgartner R, Forteza MJ, Ketelhuth DFJ. Cytokine. 2017 Sep 9. pii: S1043-4666(17)30259-4.
  • Adaptive Response of T and B Cells in Atherosclerosis. Ketelhuth DF, Hansson GK. Circ Res. 2016 Feb 19;118(4):668-78.
  • Immunostaining of Lymphocytes in Mouse Atherosclerotic Plaque. Gisterå A, Ketelhuth DF. Methods Mol Biol. 2015;1339:149-59.
  • The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease. An emerging field. Polyzos KA, Ketelhuth DF. Hamostaseologie. 2015;35(2):128-36.
  • Modulation of autoimmunity and atherosclerosis - common targets and promising translational approaches against disease. Ketelhuth DF, Hansson GK. Circ J. 2015;79(5):924-33.
  • T cell-based therapies for atherosclerosis. Ketelhuth DF, Gisterå A, Johansson DK, Hansson GK. Curr Pharm Des. 2013;19(33):5850-8.
  • Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall. Ketelhuth DF, Hansson GK. Thromb Haemost. 2011 Nov;106(5):779-86