Navigation Menu

Medical epigenetics

Medical epigenetics


The genetic material, or genome, which is identical in all cells of an individual, is composed of DNA and associated proteins, which together make up the chromatin. Chromatin is nessecary for the packaging of the genetic material in every cell nucleus of the organism, as well as for the regulation of gene programs, which are different in all cell types and which can be altered in disease. This is done partly by employing epigenetic mechanisms.

We are studying the integration between these mechanisms, the genome and environmental exposures in order to understand risks of autoimmune inflammatory chronic diseases that affect 1/3 of the Swedish population, a great burdon on individuals and society. The coordination of the genome with the epigenetic make-up is likely of great importance.

Rheumatoid arthritis (RA), a systemic inflammatory disease primarily affecting the flexible joints, and multiple sclerosis (MS), a neurological disease affecting the function of nerves in the central nervous system, are both chronic autoimmune diseases associated with inflammation.

Our research is connecting individual epigenetic profiles with genetic background, lifestyle and disease risks. We try to find epigenetic molecular causes to why individuals with certain genetic make-up combined with certain environmental exposures are affected by RA or MS, and why therapy responses are different among affected individuals. To achieve this, we use advanced technology and bioinformatics with clinical patient material.

Donations

Donations

   If you would like to support this area of research

   you could do that by using Swish transfer. 

  Our Swish number is 123-245 79 76

 

Always state the name of group leader in order for us to allocate the gift properly. 

Or you can also use the following accounts:

BG: 628-4418
PG: 514114-8

Always state the name of group leader in order for us to allocate the gift properly. 

If you are outside of Sweden, please use the following information:

Bank: SEB, Stockholm, Sweden
Account No. 5201-11 370 12
Iban-number: SE16 5000 0000 0520 1113 7012
Bic-code (the bank´s electronic address): ESSESESS
Account holder: Center for Molecular Medicine Foundation
L8:05, Karolinska University Hospital
171 76 Stockholm, Sweden

GruppChefPortlet

Group leader

Tomas Ekström

E-mail

tomas.ekstrom@ki.se

Job title

Professor

House

L8:00

GroupInformationPortlet

Research

Bio statistics, Cell, molecular and structural biology, Environmental medicine, Epidemiology, Genomics, Infection and inflammation, Neuroscience, Psychiatry, Psychology, Toxicology

Disease

Malaria, Rheumatoid arthritis

Competence/titles

Animal models, Cell culture, Cohort study, Epigenetics, Immunohistochemistry, Microscopy, Omics