Viral etiology in epilepsy

Viral etiology in epilepsy

In search for viruses in the brain we investigated epilepsy brain tissue removed as treatment for the disease. To our surprise some of the epilepsy patients had HHV-6B in their brain tissue and we are interested in understanding if this could be an essential part of the disease mechanism in epilepsy. The virus is inducing epigenetic modifications near the telomeric ends of the chromosomes, especially chromosome 17, and is associated with viral integration.

Publications

Engdahl E, Dunn N, Niehusmann P, Wideman S, Wipfler P, Becker AJ, Ekström TJ, Almgren M, Fogdell-Hahn A. Human herpesvirus 6B induces hypomethylation on chromosome 17p13.3 correlating with increased gene expression and virus integration. J Virol. 2017 Mar 15. 

Fotheringham J, Donati D, Akhyani N, Fogdell Hahn A, Vortmeyer A, John D. Heiss JD, Williams E, Weinstein S, Bruce DA, Gaillard WD, Sato S, Theodore WH, and Steven Jacobson. Association of human herpesvirus 6B with mesial temporal lobe epilepsy. PLoS Med. 2007 May;4(5):e180.