Viral etiology in MS

Viral etiology in MS

The etiology of MS is unknown and the only treatments available today are working by suppressing the immune system. To be able to cure the disease we need to understand the triggering mechanisms and identify targets for prevention. We are investigating if the triggering of the disease could be due to viruses fooling the immune system to start an attack on the body’s own tissue (autoimmunity). When viral particles are formed from a host cell, many viruses incorporate part of that cells membrane and proteins into the viral particle. To understand how this might cause MS, it is important to investigate how viral particles are formed in cells of the brain and how these viral particles are handled by the immune system. Our candidate virus is human herpesvirus 6A (HHV-6A).

 

Publications

Hammarstedt M, Ahlqvist J, Jacobson S, Garoff H and Fogdell-Hahn. Purification of infectious Human herpesvirus 6A virions and association of host cell proteins. Virology Journal 4:101 (2007). 

Ahlqvist J, Donati D, Martinelli E, Akhyani N, Hou J, Major EO, Fogdell-Hahn A, Jacobson S (shared senior authorship). Complete replication cycle and acquisition of tegument in nucleus of Human herpesvirus 6A (HHV-6A) in astrocytes and in T-cells. J Med Virol. 2006 Dec;78(12):1542-53.